ID A0A3B4YXE8_9TELE Unreviewed; 325 AA.
AC A0A3B4YXE8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000256|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000256|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000256|HAMAP-Rule:MF_03008};
DE AltName: Full=eIF-3-beta {ECO:0000256|HAMAP-Rule:MF_03008};
DE AltName: Full=eIF3 p36 {ECO:0000256|HAMAP-Rule:MF_03008};
GN Name=eif3i {ECO:0000313|RefSeq:XP_008294825.1};
GN Synonyms=EIF3I {ECO:0000256|HAMAP-Rule:MF_03008}, EIF3S2
GN {ECO:0000256|HAMAP-Rule:MF_03008};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000000920.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000000920.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008294825.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC EIF3M. {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the WD repeat STRAP family.
CC {ECO:0000256|ARBA:ARBA00038394}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000256|HAMAP-
CC Rule:MF_03008}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008294825.1; XM_008296603.1.
DR AlphaFoldDB; A0A3B4YXE8; -.
DR STRING; 144197.ENSSPAP00000000920; -.
DR Ensembl; ENSSPAT00000000933.1; ENSSPAP00000000920.1; ENSSPAG00000000719.1.
DR GeneID; 103368277; -.
DR CTD; 8668; -.
DR GeneTree; ENSGT00940000161371; -.
DR OrthoDB; 5474889at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19877; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I; 1.
DR PANTHER; PTHR19877:SF1; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_03008};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_03008}; Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 6..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 48..89
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 145..194
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 184..225
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 281..311
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 325 AA; 36353 MW; BDF62415A89B0A1F CRC64;
MKPILLQGHE RSITQIKYNR EGDLLFSVAK DTVANVWYSV NGERLGTYNG HTGAVWCVDC
DWDTKNVLTG SADNSCRLWD CETGKQLALL NTNSAVRTCG FDFSGNIIMF STDKQMGYQC
YLNFFDLRDP QQIDDNQPYL SVPCSDHKIT SAVWGPLGEF VIAGHENGEI NQFSAKSGEV
LKKIKEHTKQ INDIQPSVDL TIFITASKDN SAKLFDSTSL DHIKTFKTER PVNSAAISPI
MDHVVMGGGQ EAMEVTTTST RIGKFEARFF HAAYEEEFGR VKGHFGPINC VAFHPDGKSY
SSGGEDGYTR IHYFDPQYFD FELEA
//