ID   A0A3B4YXS9_9TELE        Unreviewed;       760 AA.
AC   A0A3B4YXS9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Numb-like protein {ECO:0000256|PIRNR:PIRNR017607};
GN   Name=LOC103364881 {ECO:0000313|RefSeq:XP_008290385.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000001065.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000001065.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_008290385.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in the process of neurogenesis.
CC       {ECO:0000256|PIRNR:PIRNR017607}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR017607}.
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DR   RefSeq; XP_008290385.1; XM_008292163.1.
DR   AlphaFoldDB; A0A3B4YXS9; -.
DR   Ensembl; ENSSPAT00000001084.1; ENSSPAP00000001065.1; ENSSPAG00000000812.1.
DR   GeneID; 103364881; -.
DR   CTD; 9253; -.
DR   GeneTree; ENSGT00940000160957; -.
DR   OrthoDB; 2913102at2759; -.
DR   Proteomes; UP000261400; Unplaced.
DR   Proteomes; UP000694891; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-UniRule.
DR   GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd01268; PTB_Numb; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR016698; Numb/numb-like.
DR   InterPro; IPR010449; Numb_domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR47368; NUMB; 1.
DR   PANTHER; PTHR47368:SF4; NUMB-LIKE PROTEIN; 1.
DR   Pfam; PF06311; NumbF; 1.
DR   Pfam; PF00640; PID; 1.
DR   PIRSF; PIRSF017607; Numb/numb-like; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR017607};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|PIRNR:PIRNR017607};
KW   Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694891}.
FT   DOMAIN          59..184
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   REGION          22..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          429..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..760
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..448
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        649..712
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        744..760
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   760 AA;  80082 MW;  00F7A2DCE6FCC9A0 CRC64;
     MSSWGEMGEA IELSTREHVT PEMNKLRQSL RRKKPTYVPE ASRPHQWQAD EEAVRKGKCN
     FAVRYLGLVE VEESRGMHVC EEAVKKLKVS GKKTVKAVLW VSADGLRVVD DKTKDLIVDQ
     TIEKVSFCAP DRNYDKAFSY ICRDGTTRRW MCHCFMALKD SGERLSHAVG CAFAACLERK
     QRREKECGVT ASFDASRTSF VREGSFRGNS SCSQQGSSSE RDDKLQEKKK DQPSVIPALP
     PGTASPPQGA ASPMDRPEPG GPHAIPRRHA PIEQLVRQGS FRGFPALSQK NSPFKRQLSL
     RLNDLPSTLQ RKTDFQADNP DMDMGMPCEG DNSINALCSQ INTSFAKPSD ELFSNPSMSA
     NGPPACTVPP VLPPPPAPLQ ATSSWVQAEP PLHSPPPVSV AMQMQMQSGH KRTPSEAERW
     LEEVSKAVKA QQTPPPGPTI PTIPGPPPIS SHQMSTQAVL PAAPVSTVPM SLGTMSKPLI
     SGPSALPGQA PMPLPPMSIS SVPLIPGPPV SGPPMSLPSM SIPTMSGPSM SGAPMLQPSL
     PGPPGSLPSS MQPFPLAFDT TPAPVGMFAS QPVQPAFVPM QTYMPGLASS MTYPNASVPV
     VGITPSQMVA NVFCTATGSS GAGGAMGSAS GGSKVAALHS YPGTSGAAGH SGGFSTPPFS
     STPPLSSALN GLPPHSSATS ALQNGTSGGG GNGGSGSSWP PEGSQLTAPV VSDSQDDDRF
     EAKWAALESK PAPQQPGNKA PAAAANPFSN NLQKTFEIEL
//