ID   A0A3B4YY49_SERLL        Unreviewed;       986 AA.
AC   A0A3B4YY49;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Patched domain containing 1 {ECO:0000313|Ensembl:ENSSLDP00000033096.1};
GN   Name=PTCHD1 {ECO:0000313|Ensembl:ENSSLDP00000033096.1};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000033096.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000033096.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   AlphaFoldDB; A0A3B4YY49; -.
DR   STRING; 1841481.ENSSLDP00000033096; -.
DR   Ensembl; ENSSLDT00000034020.1; ENSSLDP00000033096.1; ENSSLDG00000025346.1.
DR   GeneTree; ENSGT00940000157080; -.
DR   OrthoDB; 2876883at2759; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796:SF36; PATCHED DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        444..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        602..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          328..466
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          509..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..552
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..577
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  109534 MW;  A02018776E0EA0B5 CRC64;
     MLGSAPGLSG RWERLEPRPR ARMLRQVLHA GLRTSFHALG RFVAGHPVFF ASAPVLLSIL
     LGASFSRYRV EEDVESLLAP KHSLAKIEGN LVDSLFPVNR SKHALYSDLQ TPGRYGRVIV
     TTRKGSVLDP VHLDTILKLH RRIYQMQVTV PATGFNSFNY SFSYLCLPDD KNVCIIDDII
     RAMEEIQSAR TSNRSVPVLR YPITQLADGR QAYIGHQLGG VQGWGPTGAV RGLGTGARGE
     GVRSARALQL TYYLQARGGL MDRVAGQWEK AFCAELQHFA ALHPKLGLYP STSSSLRTDF
     QFSSVLARRP LLASLGVCGV LAVLCCSMRD CVRSKPWLGL LALLSITLSG LTAAGILNLT
     GATYNSTYLG IPFVMLGHGL FGSFEMLSSW RRTREDQHVK ERVASVFEDV MLRFSGSTML
     HLMTLGLAAS PLTNMEAVRL FCRTAALAVT ISYVYMLSFY SSCLVFTGYL ETGYRHGCFC
     RRVPKPDRLD SKPAWYRCLM YTRYQDETQT TNPPHVVGHS HAHPPNPNLT HTHAHTHPHS
     ANNPNSHGHG HVANSTHAHP HPHPQTHPNT STDPHPQDSH LLLGCVRRCY GDWITNTYVK
     PFVVLLYLVY ISFGLMGFLQ VTQGSDPSAL VAMDTTTVLY TRAQQRYFSS YSPVIGFYIY
     ESAPYWNASV QRDLLEYAKG FQRISWLEAY LNYLTDRNQS TSQSRENFTR TLRHSFLREP
     QFAHFADDII FAERGQGEEP DVAASRIFLV AKTTENKREE MSVLLDTLRR LSLTSRVRFL
     IFNPSFVYLD RYAAAVSSPL RHSLLAVLFL LGLSSLAVVE PLVSVWLGLT LLSVQFGVLG
     FMTLWGVELD CMSVLCLISA LGHSADCSGP LLCGFASGRG ESRTRWVRVA LERHGVPSLQ
     TLICYSAALV PVGSVRSNLT RTLFRCLTLT AGCSALHTLA FLPTLLTFLP PSKSRGHRPG
     GDGQRQEVEC VEMNDSTRVV DQITTV
//