ID   A0A3B4YZG1_9TELE        Unreviewed;       983 AA.
AC   A0A3B4YZG1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Holocarboxylase synthetase {ECO:0000313|Ensembl:ENSSPAP00000002018.1};
GN   Name=HLCS {ECO:0000313|Ensembl:ENSSPAP00000002018.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000002018.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000002018.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC       {ECO:0000256|ARBA:ARBA00009934}.
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DR   AlphaFoldDB; A0A3B4YZG1; -.
DR   STRING; 144197.ENSSPAP00000002018; -.
DR   Ensembl; ENSSPAT00000002051.1; ENSSPAP00000002018.1; ENSSPAG00000001558.1.
DR   GeneTree; ENSGT00390000002960; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   CDD; cd16442; BPL; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR003142; BPL_C.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   NCBIfam; TIGR00121; birA_ligase; 1.
DR   PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR   Pfam; PF02237; BPL_C; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598}.
FT   DOMAIN          711..909
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   983 AA;  109037 MW;  FD8FCFDAAB89F2EE CRC64;
     MHQFAICQPL INLKQEDEEN RKTKLHIGSD VTSKVHVGEQ KDNKDAPFRV RRNKMLITLC
     YVYLWVRFHK CYSALIRNGL SRLNSSSFSF SVCSCSASEP AATPPTGRHA AGRRHHSLLP
     LDDNVFLQLG NKAVYVTEPQ ACDDLSKWTL LFGSSLVCGP RIENISFIIE ATGNRVGYPS
     PHTSNKKVLK WSDYCLPLAR SPGQPFRAVA QASVDNFSRL GVAFIEDRLQ LDNGLMPSKI
     VPVLLHESTL SELLEKQCPQ RPKTLTSLFL GSSQNEKVFP GLLPHHLPAD HQHVQCRKGS
     LLLIPEVKRS LEERRGSEPL LNTKDLGPVS DLGEHCSENH HHMEGHGHHL HLSSCHECLE
     LENSTILSVK YASVENIPDL PDDKSVGLDS GDECLEELEH DAQVSSGQSG GLDCNSKPPN
     VLVYTGGCQE RYQVVHQLLS ECINMENNII YPLQPQQALN DPWLENTRLL VLAEEETLSP
     QLQTRFLTYL SQGGKVLGLA STLCPAGLCL EVRERQHMQV SRLSFTREDS TELELSMLAS
     GKVYIRDTQG GGEVELWGEL KGNVPHQRDM VIVRVTHGDD GEAVLCQVHF EIAADCQNLT
     SEGFDKVKLS NALRYEVLTE ILTSLGLNCE LNQTPTPSPV YLLATSQEAK TNCLKWLQKH
     ANVDGVLTKS KSSLRMVSTS EFQDGSLLPE GSLALVTDSS DSQSWPQFSM ETYRKNLKTS
     LLGHTVLFAE IVTSTMDLFE GLTVHIPKDV GLIAVAAQQC QGKGRGRNVW LSPLGCAMFT
     LRVQVELSST LGQRIPFVQH LAALAVVEAV RTLPGYQDID LRVKWPNDIY YSNLMKLGGV
     LVTSTVIGST FHLLIGCGFN VTNSNPTVCI NDLIRRYNIQ HDCSLEPLSC DQLIARTVNC
     LDALITSFQL GGPDAVLPTY YKRWLHSGSQ VRLWTEDGLE AQVVGLDQYG FLQVHSKDQG
     LVSVEPDGNS FDMLKNLLII KQH
//