ID A0A3B4Z111_SERLL Unreviewed; 599 AA.
AC A0A3B4Z111;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=FMRP translational regulator 1 {ECO:0000313|Ensembl:ENSSLDP00000028739.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000028739.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000028739.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection,
CC dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic
CC spine {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium tip
CC {ECO:0000256|ARBA:ARBA00004495}. Cell projection, growth cone
CC {ECO:0000256|ARBA:ARBA00004624}. Cell projection, neuron projection
CC {ECO:0000256|ARBA:ARBA00004487}. Chromosome, centromere
CC {ECO:0000256|ARBA:ARBA00004584}. Cytoplasm, Cytoplasmic
CC ribonucleoprotein granule {ECO:0000256|ARBA:ARBA00004331}. Cytoplasm,
CC perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}. Presynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034111}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034109}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR AlphaFoldDB; A0A3B4Z111; -.
DR SMR; A0A3B4Z111; -.
DR STRING; 1841481.ENSSLDP00000028739; -.
DR Ensembl; ENSSLDT00000029587.1; ENSSLDP00000028739.1; ENSSLDG00000022042.1.
DR GeneTree; ENSGT00950000183189; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0032433; C:filopodium tip; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd22509; KH_I_FMR1_rpt2; 1.
DR CDD; cd22512; KH_I_FMR1_rpt3; 1.
DR CDD; cd20474; Tudor_Agenet_FMR1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR032196; FMR1_C2.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047440; KH_I_FMR1_rpt2.
DR InterPro; IPR047436; Tudor_Agenet_FMR1_rpt2.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF4; SYNAPTIC FUNCTIONAL REGULATOR FMR1; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF16098; FXMR_C2; 1.
DR Pfam; PF12235; FXMRP1_C_core; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF17904; KH_9; 1.
DR Pfam; PF18336; Tudor_FRX1; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 2.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 4..49
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT DOMAIN 62..114
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 381..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 65494 MW; 29CBBE6F5F12A1F5 CRC64;
MDELVVEVRG TSGAFYKAFV KDVHEGSVTV AFENWQPERQ IPFQDVRFPP PTGFCKEINE
SDEVEVYSRA NDKEPCGWWL AKVRMVKGEF YVIEYAACDA TLNEIVTLER LRPVNPNKPA
TKTTFIKIRL DVPEDLRQCS KESAHKDFKK AVGAFSVIYD SEKKQLVILS VNEVTTKRAN
MMSDMHFRSL RTKLSLMLRN EEASRQLESS RQLASRFHEQ FAVRDDLMGL AIGTHGANIQ
QARKVPGVTN IDLDEETCTF HIYGEDQDAV RVARSFLEFS EDVIKVPRNL VKVIGKNGKL
IQEVVDKSGV VRVRIEPEND KKPSAAAAAA ADEQGMVPFV FVGTKESISN ATVLLDYHLN
YLKQEVDQLR LERLQIDEQL RQIGGGGGGG GTGPRNPKDK TYVFDNGMGL GMGRGAGGGG
GGGKPYTGGG GRGGRGRRGG TNSEASNASE TESDHRDELS DWSLAPTEEL MTGGGTLPRR
TDGRKRAGGG GPRGRGGRGR GGGGYKDDMQ WSEPRPRHVR DPKTRGQEDT LQQIRVDGNN
ERSVQHSSGG RGGGGPSSSQ GGVGASGEGP SRHHHQRPIR DRGMKKDKQD APPLVNGVS
//
