ID   A0A3B4Z465_9TELE        Unreviewed;       936 AA.
AC   A0A3B4Z465;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Holocarboxylase synthetase {ECO:0000313|Ensembl:ENSSPAP00000002026.1};
GN   Name=HLCS {ECO:0000313|Ensembl:ENSSPAP00000002026.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000002026.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000002026.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC       {ECO:0000256|ARBA:ARBA00009934}.
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DR   AlphaFoldDB; A0A3B4Z465; -.
DR   Ensembl; ENSSPAT00000002059.1; ENSSPAP00000002026.1; ENSSPAG00000001558.1.
DR   GeneTree; ENSGT00390000002960; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   CDD; cd16442; BPL; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR003142; BPL_C.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   NCBIfam; TIGR00121; birA_ligase; 1.
DR   PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR   Pfam; PF02237; BPL_C; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598}.
FT   DOMAIN          664..862
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   936 AA;  103931 MW;  2F914F1C0059A058 CRC64;
     MHQFAICQPL INLKQEDEEN RKTKLHIGSD VTSKVHVGEQ KDNKDAPFRV RRNKMLITLC
     YVYLWVRFHK CYSALIRNGL SRLNSSSFSF SVCSCSASEP AATPPTGRHA AGRRHHSLLP
     LDDNVFLQLG NKAVYVTEPQ VLKWSDYCLP LARSPGQPFR AVAQASVDNF SRLGVAFIED
     RLQLDNGLMP SKIVPVLLHE STLSELLEKQ CPQRPKTLTS LFLGSSQNEK VFPGLLPHHL
     PADHQHVQCR KGSLLLIPEV KRSLEERRGS EPLLNTKDLG PVSDLGEHCS ENHHHMEGHG
     HHLHLSSCHE CLELENSTIL SVKYASVENI PDLPDDKSVG LDSGDECLEE LEHDAQVSSG
     QSGGLDCNSK PPNVLVYTGG CQERYQVVHQ LLSECINMEN NIIYPLQPQQ ALNDPWLENT
     RLLVLAEEET LSPQLQTRFL TYLSQGGKVL GLASTLCPAG LCLEVRERQH MQVSRLSFTR
     EDSTELELSM LASGKVYIRD TQGGGEVELW GELKGNVPHQ RDMVIVRVTH GDDGEAVLCQ
     VHFEIAADCQ NLTSEGFDKV KLSNALRYEV LTEILTSLGL NCELNQTPTP SPVYLLATSQ
     EAKTNCLKWL QKHANVDGVL TKSKSSLRMV STSEFQDGSL LPEGSLALVT DSSDSQSWPQ
     FSMETYRKNL KTSLLGHTVL FAEIVTSTMD LFEGLTVHIP KDVGLIAVAA QQCQGKGRGR
     NVWLSPLGCA MFTLRVQVEL SSTLGQRIPF VQHLAALAVV EAVRTLPGYQ DIDLRVKWPN
     DIYYSNLMKL GGVLVTSTVI GSTFHLLIGC GFNVTNSNPT VCINDLIRRY NIQHDCSLEP
     LSCDQLIART VNCLDALITS FQLGGPDAVL PTYYKRWLHS GSQVRLWTED GLEAQVVGLD
     QYGFLQVHSK DQGLVSVEPD GNSFDMLKNL LIIKQH
//