ID A0A3B4Z483_9TELE Unreviewed; 916 AA.
AC A0A3B4Z483;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Focal adhesion kinase 1-like {ECO:0000313|Ensembl:ENSSPAP00000003535.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000003535.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000003535.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A3B4Z483; -.
DR STRING; 144197.ENSSPAP00000003535; -.
DR Ensembl; ENSSPAT00000003601.1; ENSSPAP00000003535.1; ENSSPAG00000002665.1.
DR GeneTree; ENSGT00940000155113; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0007172; P:signal complex assembly; IEA:InterPro.
DR CDD; cd13190; FERM_C_FAK1; 1.
DR CDD; cd05056; PTKc_FAK; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.5.540; Single helix bin; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR041390; FADK_N.
DR InterPro; IPR049385; FAK1-like_FERM_C.
DR InterPro; IPR041784; FAK1/PYK2_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR036137; Focal_adhe_kin_target_dom_sf.
DR InterPro; IPR005189; Focal_adhesion_kin_target_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46221; FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46221:SF11; NON-SPECIFIC PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF21477; FERM_C_FAK1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18038; FERM_N_2; 1.
DR Pfam; PF03623; Focal_AT; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF68993; FAT domain of focal adhesion kinase; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273}.
FT DOMAIN 373..614
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 103518 MW; DC3B56EB1C1B4A9B CRC64;
MASSSYLESN LNHSAAGPGT SSSAGGLERP PGSMDRVLKI FHYFETNSEP CTWASNIRHG
DATDVRGVIQ KIAEIHKLRC VSSLGLRLTH LHSDALHWLH PDLAINFTCC SVKSDYMQHI
ADQVDQDVAL KLGCLEIRRF FREMPGNALD KKSNYELLEN SWKCVLFFFP LRCVCQAKAL
RKQIQQTFKQ FANLNDEQSI HKFFEILSPI YRFDKECFKC ALGSSWVISV ELAIGPEEGI
SYLTDKGSTE LLVIEIRSGD RQRSGLKDAN RPLRLHPLTV TTASLTTAEN MADLIDGYCR
LVSSASHSFI VRVHKEGDRA LPSIPKFIVF FDSFPSCLHS GSAETDDYAE IIDEEDTYTM
PSTRDYEIQR DRIELGRCIG EGQFGDVHQG VYISPVLPSV FSNCSNLTMR QFDHPHIVKL
MGVITENPVW IIMELCTLGE LRSFLQVRKY SLDLATLILY SYQLSTALAY LESKRFVHRD
IAARNVLVST VDCVKLGDFG LSRYMEDSSY YKASKGKLPI KWMAPESINF RRFTTASDVW
MFGVCMWEIL MYGIKPFQGV KNNDVIGRIE NGERLAMPPQ CPPTLYSLMT KCWSYDPSKR
PRFTELKTQL STILEEEKVQ QKERNRMEMR RQVTVSWDSG GSDEAPPKPS RPGYPSPRSS
EGFYPSPQHP GHYQDGAVDM QQCVEQQCLL MEEQLMIQQQ QMEADQRWLE QEERLLVTHT
AHTVENTEIC KTEHAAPPKK PPRPSAQSQL GGLACLNTGD SYNDGVKLQP QEISPPPTAN
LDRSNDKVYE NVTGLVKAVI EMSSRIQPAP PEEYVPMVKD VGLALRTLLA TVDETLPQLP
ASTHREIEMA QKLLNSDLAE LIGKMKLAQQ YVMTSLQQDY KKQMLTAAHA LAVDAKNLLD
VIDQSRLKMM AQSRPH
//
