ID A0A3B4Z5I5_SERLL Unreviewed; 403 AA.
AC A0A3B4Z5I5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Toll like receptor 2 {ECO:0000313|Ensembl:ENSSLDP00000030314.1};
GN Name=TLR2 {ECO:0000313|Ensembl:ENSSLDP00000030314.1};
OS Seriola lalandi dorsalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Carangidae; Seriola.
OX NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000030314.1, ECO:0000313|Proteomes:UP000261360};
RN [1] {ECO:0000313|Ensembl:ENSSLDP00000030314.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3B4Z5I5; -.
DR Ensembl; ENSSLDT00000031190.1; ENSSLDP00000030314.1; ENSSLDG00000023305.1.
DR GeneTree; ENSGT00940000156323; -.
DR Proteomes; UP000261360; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 202..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..382
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 403 AA; 47369 MW; 8373D1F94E972628 CRC64;
KTKFYELPYY NNCSFSHNLL LLIMITVKPQ YDVFLSVLTR VSFRGICKPI NISRNDLRSI
NSQLFTKLED LKNIDMSGNV FHTIPETCKW LPNLRFLNLS STHLTKVGSL HILDLSDNKL
SVFNIKLPFL TELYISGNKI GSLPDSSLYL RLESISIQNN DLQKFSSNNL NDYKNLKSDL
VKHRVRIRKK NVRLSVFESH RALSFSLLCS GILVMFLLFL HLCHKYNVVW YIKMTLAYLK
AERKPKLKTG ELEYDGFVSY SEMDSGWVKA HLVPELEQCE PPFRLCLHKR DFVPGGWIID
NIMDAIEKMS EWCKYELDYT HFRLFDQNDD TVVLILLEPI DKNTIPEKFC KLRRVMNSRT
YLEWPDDDNQ IARFWQSLRT AIKIPDPVGE RTILHYCYEI RQD
//
