ID   A0A3B4ZAI0_SERLL        Unreviewed;       418 AA.
AC   A0A3B4ZAI0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Nodal homolog {ECO:0000313|Ensembl:ENSSLDP00000032144.1};
OS   Seriola lalandi dorsalis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Carangidae; Seriola.
OX   NCBI_TaxID=1841481 {ECO:0000313|Ensembl:ENSSLDP00000032144.1, ECO:0000313|Proteomes:UP000261360};
RN   [1] {ECO:0000313|Ensembl:ENSSLDP00000032144.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B4ZAI0; -.
DR   STRING; 1841481.ENSSLDP00000032144; -.
DR   Ensembl; ENSSLDT00000033057.1; ENSSLDP00000032144.1; ENSSLDG00000024690.1.
DR   GeneTree; ENSGT00940000163919; -.
DR   OrthoDB; 5393576at2759; -.
DR   Proteomes; UP000261360; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13759; TGF_beta_NODAL; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..418
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017230161"
FT   DOMAIN          295..418
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          199..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  47523 MW;  9B9B598CA0D040B1 CRC64;
     MEARVLTVFC MLLLDSVGLV LSAQRFRHHT RLETSLAFRN LSVNYRSRYP LYMMQLYRSF
     RTADFSSPAA VNTVITQGDN PSAHSSDSVL SLMARGCHQV GERWTVTFDM STISTSDLVQ
     LAELRIWLPA FSASKRATVD LYHSRKQSCD PGSTSCQDEH LFLGSFATSP SSTKSSWKVF
     NVTALLKYWL YQGDSVSSQE ASGQSETEHG SGAEEEGAIT GRSLFKNLGM RQRKIHHPTM
     NQVMMVIFSK HNLPQEGHSA YSLIHTVENS KYVTTDRLSS SDSQSRRYKR NRMERMRVAA
     GAAPTAEPAA EPVQRPLCRK VDMWVDFDHI GWDEWIVHPK RYNAYRCEGE CPIPLDESFH
     PTNHAYMQSL LHHHHPERVT CPSCVPTRLS PLSMLYYEND DLALRHHEDM IVEECGCH
//