ID   A0A3B4ZBW5_9TELE        Unreviewed;      1111 AA.
AC   A0A3B4ZBW5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO8 {ECO:0000313|Ensembl:ENSSPAP00000004926.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000004926.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000004926.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A3B4ZBW5; -.
DR   STRING; 144197.ENSSPAP00000004926; -.
DR   Ensembl; ENSSPAT00000005023.1; ENSSPAP00000004926.1; ENSSPAG00000003786.1.
DR   GeneTree; ENSGT00940000157019; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF33; ANOCTAMIN; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          236..854
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          539..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          660..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          864..942
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          955..1111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        550..564
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..701
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        864..921
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        955..977
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1004..1039
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1062..1079
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1111 AA;  124087 MW;  0574F62DEF7A3A7A CRC64;
     ASSAEVVRGP NVAATAVVKC KMPSVEPAAG LSVQDKLFGK RLLQAGRHIM SHKSWMKTVP
     TENCDVLMTF ADTTDDHTLL WLLNHIRLGI PELIIQIRHH KHTRVYAFFV TATYENLLRG
     AEEMGLRKAV KPEFGGGTRS FSCEEDYIYE NIESELCFFT SQERQSIIKY WLDNLRAKHG
     EVLHNISFLE GQPIIPELSA RGVIQQVFPL HEQRILSQLM KSWVQAVCEK QPLDDICDYF
     GVKIAMYFAW LGFYTTSMLY PAVIGFVLWM LTESDQTSRD ICCVVFALFN VVWATLFLER
     WKRRGAELAY KWGTLDTPAE SLEEPRPQFR GVKRCSPITG CEEFYYPPWR RRVFRWLVSL
     PICILCLCFV FLVMLICFEL QEFVMGIKEM PRLARFIPKI MLAITVTACD EVYRKIACWL
     NDMENYRLQS AYEKNLIIKM VLFQFVNSYL SLFYIGFYLK DMERLKEMLA TLLIIRQFLQ
     NVKEVLQPYL YERHKLGELT LRAVWDLLLS VLLKYARLAG YQARSGAAGK KKCLNGGCGV
     PDEEEGGERD EADSGRFSEG ETEEESLIDC GLKLRKVSFI EKVDRRPACA GPPMDNSFLE
     EGSPTMVEKG MDPASVFEMC DDDDDNGIHD VKDSAGGGTE GVNAAAAAAA AAAAAAAGSA
     ASLPSGSESS TSLRHRRRGR SAERLEAKTK RESWMDPPEE RESTTLTQAE MESCMQTYAD
     TFQDYQEMFV QFGYVVLFSS AFPLAAMCAL INNIIEIRSD AFKLCTGLQR PFGVRVESIG
     QWQTAMEAMG LIAIIVNCYL IGQCGQLQRL FPWLSPEMAI ISIVILEHFA ILLKYVIHVA
     IPDIPTWVRE EMAKLDYQRR EAFKKHERQA QQHYQQLQRR KREEEERQRQ AEHMARRERE
     RDDSKGDSSG DHHHDKSHGS KSRSGGGGGG SGSDKPKRPS SLLANNNVMK LKQIIPLQSK
     FSSGGARSPQ SPTGSEPKLP GFLSFKFLKS PENKKEGAAA SVAAATATNA TATASSSSSS
     SLSGSSSQER SQSPSKAFNP GKLFNFGKSE GGTCVNGAPL PRSGEGSSSQ SSERQPSRSD
     LNGVPDEIPS PGGEGSENGH STDLEPAGSK I
//