ID A0A3B4ZDR0_9TELE Unreviewed; 2327 AA.
AC A0A3B4ZDR0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Triple functional domain protein {ECO:0000313|Ensembl:ENSSPAP00000004514.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000004514.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000004514.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 144197.ENSSPAP00000004514; -.
DR Ensembl; ENSSPAT00000004605.1; ENSSPAP00000004514.1; ENSSPAG00000003392.1.
DR GeneTree; ENSGT00940000154766; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 2.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11852; SH3_Kalirin_1; 1.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR InterPro; IPR028570; Kalirin_TRIO_SH3_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF106; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR Pfam; PF16609; SH3-RhoG_link; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 2.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 7.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 6.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 5..151
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 1232..1407
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1419..1531
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1596..1661
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1912..2088
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1546..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1688..1850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1867..1900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2236..2316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 693..723
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1568..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1764..1778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1821..1850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1873..1898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2259..2284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2327 AA; 264900 MW; 1309A24FB825A6E6 CRC64;
MRAMEVLPIL KEKVAFLSGG RDRRGGPVLT FPSRSNHDRI RTDDLRRLIA YLAGIPSEEV
CKHGFTVIVD MRGSKWDSIK PLLKILQESF PSCIHVALII KPDNFWQKQR TNFGSSKFEF
ETTMVSLEGL TKVVDPSQLT ADFDGSLDYN HEEWIEVRVA FEEFSGHATQ MLARLEEMQE
TVSRKDFPQD LEGARRMIEE HATLKKKVIK APIEELDTEG QRLLQRIQSS DSSSGGGVCN
ADTQGLVPRI TQLLDKLHST RQHLHQAWHV RKLQLDQCFQ LRLFEQDAEK MFDWIMHNKG
LFLAGYTEIG NNHPHAIELQ TQHNHFAMNC MNVYVNINRI MSVGNRLLES GHYASQQIKQ
ISGQLEQEWK AFAAALDERS TLLEMSASFH QKCDQYMSNV DSWCKACGEV DLPSELQDLE
DAIHHHQGLY EHITAAYSEV SQDGKALLDK LQRPLTPGSA DSLTASANYS KAVHHVLDII
HEVLHHQRQL ENIWQHRKVR LHQRLQLCVF QQDVQQVLDW IENHGEAFLS KHTGVGKSLH
RARALQKRHE DFEEVAQNTY TNADKLLEAA EQLAQTGECD PEEIYQAAHQ LEDRIQDFVR
RVEQRKVLLD MSVAFHTHVK ELWTWLEELQ KELLDDVYAE SVEAVQDLIK RFGQQQQTTL
QVTVNVIKEG EDLIQQLRDS AISSNKTPHN SSINHIESVL QQLDEAQAQM EELFQERKIK
LELFLQLRIF ERDAIDIISD LESWNEELTG QMNDFDTEDL TLAEQRLQHH ADKALTMNNL
TFDVIHQGQE LLQYVNEVQA SGVELLCDRD VDMATRVQDL LEFLHEKQQE LDLAAEQHRR
HLEQCVQLRH LQAEVKQVLG WIRNGESMLN AGLITASSLQ EAEQLQREHE QFQHAIEKTH
QSALQVQQKA EALLQANHYD MDLIRDCAES VASHWQQLML KMEDRLKLVN ASVAFYKTSE
QVCSVLESLE QEYKREEDWC GGADKLGPNC ETDHVTPMIS KHLEQKEAFL KACTLARRNA
DVFLKYMHRN SVNMPGMLSH VKAPEQQVKN ILNELLQREN RVLHFWTMRK RRLDQCQQYV
VFERSAKQAL EWIHDTGEFY LSTHTSTGSS IHHTQELLKE HEDFHITAKQ TKERVKLLIQ
LADGFCEKGH SHAGEIKKWV TAVDKRYRDF SLRMDKYRCS LEKALGISSD SNKASKDLQL
DIIPATAPGS EVKLRDAAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW
EMTSGVEEIP PGIINKEHII FGNMQDLYEF HHNIFLKELE KYEQLPEDVG HCFVTWADKF
QMYVNYCKNK PDSTQLILEH AGNYFDEIQQ RHRLANSISS YLIKPVQRIT KYQLLLKELL
TCCEEGKGEI KDGLEVMLSV PKKANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL
IRKGRERHLF LFEMSLVFSK EVKDSNGRSK YIYKSKLFTS ELGVTEHVEG DPCKFALWVG
RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTIHLRGA LKEPIHIPKA TTAKHHKGRR
DGEDLDSQGE GSSQPDTISL ASRTSQNTLD SDKLSGGCEL TVVIHDFMAS NSNELTVRRG
QTVEVLERCH DKPDWCLVRT TDRSPAQEGL VPCSMLCIAH SRSSMEMEGI FNHKDTLSVC
SNDSIMPGSS ATLQPGHGIG SHTSPGPKRP GNTLRKWLTS PVRRLSSGKA DGHVKKLAHK
HKKSREMRKS GEMTMGSQKD SDDSAATPQD ETLEERVRNE GLSSGTLSKS SSSGMQSCGE
EEGEEGADSV PLPPPMAIQQ HSLLQPDSQD DKTSSRLSVR PSSSETPSAA ELVSAIEELV
KSKMALEDRP SSLSVEQGDS SSPSFNPSDN SLLSSSSPIE EMDERRNSIL KKRHYILLEL
VETERDYVRD LGLVVEGYMS RMKEEGVPDD MKGKDKIVFG NIHQIYDWHK DFFLRELEKC
LEDPDRLGPL FLKQERRLNM YVVYCQNKPK SEHIVSEYID TYFEDLKQRL GHRLQITDLL
IKPVQRIMKY QLLLKDFLKH SKKAGLESMD LEKAVEVMCI VPKRCNDMMN VGRLQGFDGK
IVAQGRLLLQ DTFMVSDPEG SLLGRMKERR VFLFEQLVIF SEPLDKKKGF SLPGFLYKNS
IKVSCLGLED NVEGDPCKFI LTSRSTNGAV ESFVLHSAHP GVREVWTLQI SQILESQRNF
LNALTSPIEY QRNHVGASSG PCVPSMGAPG GGSSGSSVAP GVGGGSSQGS SIPSGPQGGS
RRPSRIPQPS RLPQPLRHHP GADPDGPNKM SGMEHESVFV KSVLLTQ
//