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Database: UniProt
Entry: A0A3B4ZDR0_9TELE
LinkDB: A0A3B4ZDR0_9TELE
Original site: A0A3B4ZDR0_9TELE 
ID   A0A3B4ZDR0_9TELE        Unreviewed;      2327 AA.
AC   A0A3B4ZDR0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Triple functional domain protein {ECO:0000313|Ensembl:ENSSPAP00000004514.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000004514.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000004514.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   STRING; 144197.ENSSPAP00000004514; -.
DR   Ensembl; ENSSPAT00000004605.1; ENSSPAP00000004514.1; ENSSPAG00000003392.1.
DR   GeneTree; ENSGT00940000154766; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR   CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR   CDD; cd00160; RhoGEF; 2.
DR   CDD; cd00170; SEC14; 1.
DR   CDD; cd11852; SH3_Kalirin_1; 1.
DR   CDD; cd00176; SPEC; 6.
DR   Gene3D; 1.20.58.60; -; 5.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR   InterPro; IPR028570; Kalirin_TRIO_SH3_1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR22826:SF106; DH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 2.
DR   Pfam; PF16609; SH3-RhoG_link; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF00435; Spectrin; 4.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00325; RhoGEF; 2.
DR   SMART; SM00516; SEC14; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00150; SPEC; 7.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 6.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50010; DH_2; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          5..151
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          1232..1407
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          1419..1531
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1596..1661
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          1912..2088
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1546..1591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1688..1850
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1867..1900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2236..2316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          693..723
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1568..1591
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1764..1778
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1779..1798
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1821..1850
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1873..1898
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2259..2284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2327 AA;  264900 MW;  1309A24FB825A6E6 CRC64;
     MRAMEVLPIL KEKVAFLSGG RDRRGGPVLT FPSRSNHDRI RTDDLRRLIA YLAGIPSEEV
     CKHGFTVIVD MRGSKWDSIK PLLKILQESF PSCIHVALII KPDNFWQKQR TNFGSSKFEF
     ETTMVSLEGL TKVVDPSQLT ADFDGSLDYN HEEWIEVRVA FEEFSGHATQ MLARLEEMQE
     TVSRKDFPQD LEGARRMIEE HATLKKKVIK APIEELDTEG QRLLQRIQSS DSSSGGGVCN
     ADTQGLVPRI TQLLDKLHST RQHLHQAWHV RKLQLDQCFQ LRLFEQDAEK MFDWIMHNKG
     LFLAGYTEIG NNHPHAIELQ TQHNHFAMNC MNVYVNINRI MSVGNRLLES GHYASQQIKQ
     ISGQLEQEWK AFAAALDERS TLLEMSASFH QKCDQYMSNV DSWCKACGEV DLPSELQDLE
     DAIHHHQGLY EHITAAYSEV SQDGKALLDK LQRPLTPGSA DSLTASANYS KAVHHVLDII
     HEVLHHQRQL ENIWQHRKVR LHQRLQLCVF QQDVQQVLDW IENHGEAFLS KHTGVGKSLH
     RARALQKRHE DFEEVAQNTY TNADKLLEAA EQLAQTGECD PEEIYQAAHQ LEDRIQDFVR
     RVEQRKVLLD MSVAFHTHVK ELWTWLEELQ KELLDDVYAE SVEAVQDLIK RFGQQQQTTL
     QVTVNVIKEG EDLIQQLRDS AISSNKTPHN SSINHIESVL QQLDEAQAQM EELFQERKIK
     LELFLQLRIF ERDAIDIISD LESWNEELTG QMNDFDTEDL TLAEQRLQHH ADKALTMNNL
     TFDVIHQGQE LLQYVNEVQA SGVELLCDRD VDMATRVQDL LEFLHEKQQE LDLAAEQHRR
     HLEQCVQLRH LQAEVKQVLG WIRNGESMLN AGLITASSLQ EAEQLQREHE QFQHAIEKTH
     QSALQVQQKA EALLQANHYD MDLIRDCAES VASHWQQLML KMEDRLKLVN ASVAFYKTSE
     QVCSVLESLE QEYKREEDWC GGADKLGPNC ETDHVTPMIS KHLEQKEAFL KACTLARRNA
     DVFLKYMHRN SVNMPGMLSH VKAPEQQVKN ILNELLQREN RVLHFWTMRK RRLDQCQQYV
     VFERSAKQAL EWIHDTGEFY LSTHTSTGSS IHHTQELLKE HEDFHITAKQ TKERVKLLIQ
     LADGFCEKGH SHAGEIKKWV TAVDKRYRDF SLRMDKYRCS LEKALGISSD SNKASKDLQL
     DIIPATAPGS EVKLRDAAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW
     EMTSGVEEIP PGIINKEHII FGNMQDLYEF HHNIFLKELE KYEQLPEDVG HCFVTWADKF
     QMYVNYCKNK PDSTQLILEH AGNYFDEIQQ RHRLANSISS YLIKPVQRIT KYQLLLKELL
     TCCEEGKGEI KDGLEVMLSV PKKANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL
     IRKGRERHLF LFEMSLVFSK EVKDSNGRSK YIYKSKLFTS ELGVTEHVEG DPCKFALWVG
     RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTIHLRGA LKEPIHIPKA TTAKHHKGRR
     DGEDLDSQGE GSSQPDTISL ASRTSQNTLD SDKLSGGCEL TVVIHDFMAS NSNELTVRRG
     QTVEVLERCH DKPDWCLVRT TDRSPAQEGL VPCSMLCIAH SRSSMEMEGI FNHKDTLSVC
     SNDSIMPGSS ATLQPGHGIG SHTSPGPKRP GNTLRKWLTS PVRRLSSGKA DGHVKKLAHK
     HKKSREMRKS GEMTMGSQKD SDDSAATPQD ETLEERVRNE GLSSGTLSKS SSSGMQSCGE
     EEGEEGADSV PLPPPMAIQQ HSLLQPDSQD DKTSSRLSVR PSSSETPSAA ELVSAIEELV
     KSKMALEDRP SSLSVEQGDS SSPSFNPSDN SLLSSSSPIE EMDERRNSIL KKRHYILLEL
     VETERDYVRD LGLVVEGYMS RMKEEGVPDD MKGKDKIVFG NIHQIYDWHK DFFLRELEKC
     LEDPDRLGPL FLKQERRLNM YVVYCQNKPK SEHIVSEYID TYFEDLKQRL GHRLQITDLL
     IKPVQRIMKY QLLLKDFLKH SKKAGLESMD LEKAVEVMCI VPKRCNDMMN VGRLQGFDGK
     IVAQGRLLLQ DTFMVSDPEG SLLGRMKERR VFLFEQLVIF SEPLDKKKGF SLPGFLYKNS
     IKVSCLGLED NVEGDPCKFI LTSRSTNGAV ESFVLHSAHP GVREVWTLQI SQILESQRNF
     LNALTSPIEY QRNHVGASSG PCVPSMGAPG GGSSGSSVAP GVGGGSSQGS SIPSGPQGGS
     RRPSRIPQPS RLPQPLRHHP GADPDGPNKM SGMEHESVFV KSVLLTQ
//
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