ID   A0A3B4ZFL6_9TELE        Unreviewed;      1048 AA.
AC   A0A3B4ZFL6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000005174.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000005174.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   AlphaFoldDB; A0A3B4ZFL6; -.
DR   STRING; 144197.ENSSPAP00000005174; -.
DR   Ensembl; ENSSPAT00000005275.1; ENSSPAP00000005174.1; ENSSPAG00000003943.1.
DR   GeneTree; ENSGT00940000163069; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF500; GUANYLATE CYCLASE 2G; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1048
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017212001"
FT   TRANSMEM        458..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        566..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          502..782
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          846..976
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1048 AA;  118362 MW;  840BE3C60573812C CRC64;
     MPRALHCFGM SLTLLLHFTL VSAAAAAAAA AVIVNNNGTQ PLKLLIGFQA PRNMSFPFSA
     LRLGSALQIA VDKVNTNPAL LGNYSLDFVY RDTDCRPKES LGGFIQQVWR ENVSALFGPA
     CPEEAEVTGL IASTWNIPMF GFVGQSFKMD NSEIYDSYIK IVPPLKRSAE VLVKTLEFFG
     WTHVAMIGSG LESNTWDKVD ALWKTVEDPL RAKFKLNAAV KFDTSDPQQA LCPAVIVVLT
     NRDDAMALLL EAERQGLMNG DYVFFLVQHF EVSGSVVTFD MTFIIGHKSY EGYEYYDFFD
     QVFERLKEHP FRSNLSSERE VSPYSAYLHD AVLLYAMGLK EVLKDGKNPY DGRHLLQRLK
     NKRSIRFYGA SGLVHFDEEG ERNLDYSIYD LQHTGDTTKF VPILHFDSHT KDVRPTSMFA
     SMVWPKGRPP SDIPECGFNN ELCEWLPNLV VISCATDVAL LALLVTFPVI GILALLFIGV
     LMLQKLRLQT RLDDSCWWMI SYSDITIIRE PSVRADRKKN VTYSSVSDFL QGNQVAVKYI
     KNPICCNFQK PSIVTEQMKE MKHENLVQFF GVCIDPICLV IQYCKKGSLK DILKATDVEL
     DGMFKLSFAY DIVNGLEFIH KSRLKFHGNL KPSTCLVDSR LQIKLSGFGL WEFKYGSKRE
     VMHVSWFGFA AEMYWTAPEL LRQVGLLVNG TPKGDVYSFA IILWELIPQL TKHQPLPPEI
     IMQLRTPFQG EPLRPVLSEQ LCEENINTLL RSCWNENPDH RPPFGSIRRR LRDTSPDSHA
     NILDNMVDKL EKYANHLEEV VEERTNQLTA EKARADKLLS SMLPRYIADQ LMAGNSVEPR
     SYDLVTIFFS DIVGFTSMCS VSSAMEVVTF LNDLYSLFDD IIKMYDVYKV ETIGDAYMVA
     SGLPLSNGNK HALEISTMAL HFLRSIKVFR IRHMPMESLA IRVGIHSGPV VAGVVGTTMP
     RYCLFGDTVN MASRMESNSL PMKIHISQST ADILVQEGSF ELEERGEIEM KGKGYHKTYW
     LLNKIGFNPP LIVHDSPPAD MPKLPLLT
//