ID   A0A3B4ZFY6_9TELE        Unreviewed;       822 AA.
AC   A0A3B4ZFY6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=IQ motif and SEC7 domain-containing protein 2-like {ECO:0000313|Ensembl:ENSSPAP00000005289.1};
GN   Name=IQSEC2 {ECO:0000313|Ensembl:ENSSPAP00000005289.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000005289.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000005289.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRAG family.
CC       {ECO:0000256|ARBA:ARBA00006248}.
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DR   AlphaFoldDB; A0A3B4ZFY6; -.
DR   STRING; 144197.ENSSPAP00000005289; -.
DR   Ensembl; ENSSPAT00000005392.1; ENSSPAP00000005289.1; ENSSPAG00000004074.1.
DR   GeneTree; ENSGT00940000159667; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
FT   DOMAIN          387..579
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          98..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..323
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  91544 MW;  A0794CA40ECE23BC CRC64;
     MLERKYGGQF VSRRAARTIQ TAFRQYRMNK NFERLRSSAS ESRMTRRIIL SNMRMQVHPH
     TCTVQTKEYK NRTTFMSECA TSNSVLFVLR VQYSFDERQP QGQGSAGQQG SEDAGDVDDS
     FSKQVKSLAD SMDDSLTCQS GREDSQECAW RNTSASSQRA AGRAGGGRGG LGGGAAMHED
     STTTSFSDVT LYMDEGCLPS SPLSRPASSS DTEYWGGGGG GGAGGREDSR ETEGGSNASR
     RSSTPCTECR GEYRGRAGGG GGHLPVLTIE PPSDSSVDMS DRSDERGGGG GVSSEADSPQ
     GTIKHKPNGR SQHHGHHPHL HHHHLLCSDG DNESVNSTTT NSNDDTTVNN CSSGSSSRDS
     LREPIGGATL GKQTYQRESR HSWDSPAFNN DVVQRRQYRI GLNLFNKKPE KGIQYLIERG
     FVSDTPVGIA RFILERKGLS RQMIGEFLGS RQQFNKDVLD CVLDEMDFSG MDLDDALRKF
     QAQIKVQGEA QRVERLVEAF SQRYCVCNPV LIRQFQNPDT IFILAFAIIL LNTDMYSPNV
     KPERKMKLED FIKNLRGVDN GQDIPRDLLV AIYGRIQKWE LRTNDDHVSQ VQAVERMVVG
     KKPRGLGLYL NHVLSLPHRR LVCCCQLFEV PDPNRAQRSG VHQREVFLFN DLLMVTKIFQ
     KKKTSVTYSF RQSFPLVDMQ VHTFQNTYYP HGIRLTSANP GGERKVLIVF TAPSQQDRAR
     FTSDLRESIA EVQDMEKYRV ESELEKQKGV MRPVKSEVVN GTLGRPSLDD TYASVDGLKR
     TALSSSLRDL SETGEVIVTE TSVGAFNRVL FCFLLLFFSP VK
//