ID A0A3B4ZGF9_9TELE Unreviewed; 641 AA.
AC A0A3B4ZGF9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=SRP receptor subunit alpha {ECO:0000313|Ensembl:ENSSPAP00000006676.1};
GN Name=SRPRA {ECO:0000313|Ensembl:ENSSPAP00000006676.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000006676.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000006676.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family.
CC {ECO:0000256|ARBA:ARBA00008531}.
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DR AlphaFoldDB; A0A3B4ZGF9; -.
DR Ensembl; ENSSPAT00000006814.1; ENSSPAP00000006676.1; ENSSPAG00000005103.1.
DR GeneTree; ENSGT00550000074936; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0005785; C:signal recognition particle receptor complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005047; F:signal recognition particle binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd14826; SR_alpha_SRX; 1.
DR CDD; cd17876; SRalpha_C; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.140; Signal recognition particle SRP54, nucleotide-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007222; Sig_recog_particle_rcpt_asu_N.
DR InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR InterPro; IPR036225; SRP/SRP_N.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR InterPro; IPR042101; SRP54_N_sf.
DR PANTHER; PTHR43134; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43134:SF1; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF04086; SRP-alpha_N; 2.
DR Pfam; PF00448; SRP54; 1.
DR Pfam; PF02881; SRP54_N; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SMART; SM00963; SRP54_N; 1.
DR SUPFAM; SSF47364; Domain of the SRP/SRP receptor G-proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00300; SRP54; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 212..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 613..626
FT /note="SRP54-type proteins GTP-binding"
FT /evidence="ECO:0000259|PROSITE:PS00300"
FT REGION 133..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 71473 MW; 893C51168A24128D CRC64;
MLDFFTIFSK GGIVLWCFQG AGVTESFTGP VNALIRSVIL QERSGNNSFT HEKLSLKYKL
DNEFELIFVV GFQKILTLTY VDKFIDDVQL HFRDRYKNEL EQKGALKLLN NSFEFEDDFK
VLLRDAEESS KVRSPAQMRS FKESEKSQKT VKSMIETKGG DKGKEQGGKK SKNTKKEGDE
IAWNDPIANF TPHEHQKILL TTQNSPVSLC SFSIMFYLFT YVLLFLFVFL PVCKMSEYLE
KCYIIIVIII IMFCHPSHSK SPKPQKPREK QMRVWDMGGS STKNLDYSER NGDGSSNGGE
QNQEREAFCF FLSSKKGGGF GGMFGMLKGL VGSKSLSRED MEPVLEKMRD HLIAKNVAAD
IASQLCDSVA KKLEGKVMGT FTTVASTVKQ ALQDSLVQIL QPKRRVDILR DVMEAQSQRR
PFVITFCGVN GVGKSTNLAK ISYWLIENGF TVLIAACDTF RAGAVEQLRT HQRRLNSLHP
PEKHGGRPVV QLYEKGYGKD AAGIAMEAIA YARNQAFDVV LVDTAGRMQD NAPLMTALAK
LIAVNMPDLV LFVGEALVGN EAVDQLVKFN QALADHSMSD KPRLIDGIVL TKFDTIDDKM
GAAISMTYIT GQPIVFVGTG QTYNDLRSLN ARAVVSALMK A
//
