ID A0A3B4ZHU6_9TELE Unreviewed; 901 AA.
AC A0A3B4ZHU6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK1 {ECO:0000313|Ensembl:ENSSPAP00000008468.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000008468.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000008468.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR AlphaFoldDB; A0A3B4ZHU6; -.
DR STRING; 144197.ENSSPAP00000008468; -.
DR Ensembl; ENSSPAT00000008624.1; ENSSPAP00000008468.1; ENSSPAG00000006416.1.
DR GeneTree; ENSGT00940000156253; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF541; GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Signal {ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 33..901
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027161830"
FT TRANSMEM 555..574
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 632..653
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 812..836
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 425..793
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 435..499
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 901 AA; 102161 MW; 3CC184A1F5274E3F CRC64;
MLEDDFKNQL FFNLSSSLLM VFVFLPLPPC SGGIFETRES ELVSMDELAF KFAVNNINRN
KTLMPNTTLT YDIQRINLFD GFEASRRVCD QLALGVVAVF GPSHSSSVSA VQSICNALEV
PHIQTRWKHP SVDNKDTFFI NLYPEYTAIA RAILDVVTFF KWRKLTVVYE DSTGLMRMQE
LIKAPAKFNL KIKIRQLTPG NQDARPLLKE LKKDREFFII FDCSYRMAAE LLKQLSSMGM
MTEYYHFFFT TLDLFALDLE PYRYSGVNMT GFRLLNIDDP WVTSTMDKWA MERLQGPKQE
SGLMDGVMTT DAALMYDAVF MVAVASQRAT QMTVSSLQCH RHKPWRFGPR FMNLFKEAQW
DGLTGHIVLN KTDGLRRDFD LDIISLKEDG TARIAVWNSY KGMNLTEKSG RDKNNNVTDS
LANRTLIVTT ILENPYVMVK KSEKELIGND RYEGYCLDLL KELSNILGFT YEVRLVGDGK
YGAQNDKGEW NGMVRELIDH VADLAVAPLT ITYVREKVID FSKPFMTLGI SILYRKPNGT
NPGVFSFLNP LSPDIWMYVL LACTGVSCVL FVIARFTPYE WYNPHPCNPS STLIQNNFTL
LNSFWFGVGA LMRQGSELMP KALSTRIVGG IWWFFTLIII SSYTANLAAF LTVERMDAPI
DSADDLAKQT RIEYGAVRDG STMTFFKKSK ISTYEKMWAF MSSRKNTALV KNNREGITRV
LTTDYAMLME STSIEYISQR NCNLTQIGGL IDSKGYGVGT PIGSPYRDKV TIAILQLQEE
GKLHMMKEKW WRGNGCPEED NKEANALGVE NIGGIFIVLA AGLVLSVFVA IGEFIYKARR
NADIEECMSF SAVMEELGIS LQCYKGIRRR SRPHSGARSA CIFCQPKRTA RREGGRRDSS
T
//
