ID A0A3B4ZJK5_9TELE Unreviewed; 834 AA.
AC A0A3B4ZJK5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=LOC103355494 {ECO:0000313|RefSeq:XP_008277547.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000001812.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000001812.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008277547.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00029431}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00029431}. Cytoplasmic vesicle, secretory
CC vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004644};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004644}. Melanosome
CC {ECO:0000256|ARBA:ARBA00004223}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR RefSeq; XP_008277547.1; XM_008279325.1.
DR AlphaFoldDB; A0A3B4ZJK5; -.
DR STRING; 144197.ENSSPAP00000001812; -.
DR Ensembl; ENSSPAT00000001844.1; ENSSPAP00000001812.1; ENSSPAG00000001357.1.
DR GeneID; 103355494; -.
DR CTD; 553691; -.
DR GeneTree; ENSGT00950000182881; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF68; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 1; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 401..425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 445..464
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 544..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 571..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 768..790
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 94..121
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 834 AA; 94777 MW; D9522D61C272EC7D CRC64;
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGMVQFRDL NPDVNVFQRK FVNEVRRCEE
MDRKLRFVEK EIKKANIPTV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
NFLELTELKH ILHRTQQFFD EMEDPNLLEE SSALMEGSEG GRGAPLRLGF VAGVISRERI
PTFERMLWRV CRGNVFLRKA EIEDPLEDPT TGDQVHKSVF IIFFQGDQLK NRVKKICEGF
RASLYPCPET PQERKEMLAG VNSRIDDLQM VLNQTEDHRQ RVLQAASKTM RVWFIKVRKM
KAIYHTLNLC NIDVTQKCLI AEVWCPVSDL DSIQFALRRG TERSGSTVPS ILNRMQTKQT
PPTFNKTNKF TSGFQNIVDA YGIGNYREIN PAPYTIITFP FLFAVMFGDM GHGVLMTAAA
LYLVIRESRL VAQKSDNEMF NMVFAGRYII LLMGIFSIYT GIIYNDCFSK SLNMFGSGWS
VRPMFGPKGA NWSPETLNEN AVLQLDPAVP GVFNGPYPLG IDPIWNIATN KLTFLNSFKM
KMSVILGVIH MLFGVSLSLF NHLYFKKPLN IFLGFIPEIV FMASLFGYLV LLVFYKWTAY
DAFTSKDAPS LLIHFINMCL FNYNDPTNKP LYAGQMGIQV LLVLIALACV PCMLIVKTMV
LRRQHLWKKH LGTQKFGGVR VGNGPTEDEA GIMDHDQLSQ HSEEGDEFDF GDVAVHQAIH
TIEYCLGCIS NTASYLRLWA LSLAHAQLSE VLWSMVMHLG LSSRSGGGFF GLSIIFSAFA
TLTVAILLVM EGLSAFLHAL RLHWVEFQNK FYSGQGFKFV PFSFESILEG RFDE
//
