ID A0A3B4ZKF2_9TELE Unreviewed; 422 AA.
AC A0A3B4ZKF2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Transforming growth factor beta {ECO:0000256|PIRNR:PIRNR001787};
GN Name=LOC103374198 {ECO:0000313|RefSeq:XP_008302468.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000009403.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000009403.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008302468.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Precursor of the Latency-associated peptide (LAP) and
CC Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute
CC the regulatory and active subunit of TGF-beta-2, respectively.
CC {ECO:0000256|ARBA:ARBA00034081}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR001787}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR001787,
CC ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_008302468.1; XM_008304246.1.
DR AlphaFoldDB; A0A3B4ZKF2; -.
DR STRING; 144197.ENSSPAP00000009403; -.
DR Ensembl; ENSSPAT00000009569.1; ENSSPAP00000009403.1; ENSSPAG00000007161.1.
DR GeneID; 103374198; -.
DR CTD; 559723; -.
DR GeneTree; ENSGT00940000166208; -.
DR OrthoDB; 5390486at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0009888; P:tissue development; IEA:UniProt.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR016319; TGF-beta.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR003940; TGFb2.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF249; TRANSFORMING GROWTH FACTOR BETA; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF001787; TGF-beta; 1.
DR PRINTS; PR01423; TGFBETA.
DR PRINTS; PR01425; TGFBETA2.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001787-1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR001787};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246, ECO:0000256|PIRNR:PIRNR001787};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001787};
KW Signal {ECO:0000256|PIRNR:PIRNR001787}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT CHAIN 23..422
FT /note="Transforming growth factor beta"
FT /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT /id="PRO_5041500674"
FT DOMAIN 305..422
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 50..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 317..326
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 325..388
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 354..419
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 358..421
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 387
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
SQ SEQUENCE 422 AA; 47858 MW; 01A1714636939BE6 CRC64;
MWLPRLSLLL LLRFSGVLPV EGINTCQSIN LDAQKSRRIE AVRGQILSKL RIRSPPDDDD
DDEAPVPGSV PPEVMLLYNS TRELLKERAR LGESACERES SEEDYYAKEV QRIDMKPPRT
DTNVVQPVAP NPHYRVVHFD VSGVDLTNST LVKAEFRIFR APNPQARASE QRVEIYQLLK
PDEESTSTQR YIESRTLQPR AKGAWISVEV TETIKDWVSD PENNLGLKLG VHCPCCTFVP
STNNIVPNKS EELEALFAGL DDERLRQMRK PGQVKGQADF STKTPHLILT LLPSDRVDNP
AKKNRKKRAA ATDTTTCARG SDQGCCLRSL YIDFRRDLNW KWIHEPKGYK ANFCAGNCPY
LWSANNHYNM ILPLYNKLNP EASASPCCVP QDLEPLTIMY FIGRTPRVEQ LSNMVVKSCK
CR
//
