ID A0A3B4ZMD8_9TELE Unreviewed; 454 AA.
AC A0A3B4ZMD8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Integrin-linked protein kinase {ECO:0000256|ARBA:ARBA00015063};
DE AltName: Full=59 kDa serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00032103};
DE AltName: Full=Beta-integrin-linked kinase {ECO:0000256|ARBA:ARBA00031016};
DE AltName: Full=ILK-1 {ECO:0000256|ARBA:ARBA00030970};
DE AltName: Full=ILK-2 {ECO:0000256|ARBA:ARBA00030969};
DE AltName: Full=p59ILK {ECO:0000256|ARBA:ARBA00029809};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000008836.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000008836.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}.
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DR AlphaFoldDB; A0A3B4ZMD8; -.
DR STRING; 144197.ENSSPAP00000008836; -.
DR Ensembl; ENSSPAT00000008997.1; ENSSPAP00000008836.1; ENSSPAG00000006694.1.
DR GeneTree; ENSGT00940000155956; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR GO; GO:0003211; P:cardiac ventricle formation; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0001885; P:endothelial cell development; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR GO; GO:0016203; P:muscle attachment; IEA:Ensembl.
DR GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR GO; GO:0035989; P:tendon development; IEA:Ensembl.
DR CDD; cd14057; PK_ILK; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR035692; PK_ILK.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR23257:SF967; INTEGRIN-LINKED PROTEIN KINASE; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000654; Integrin-linked_kinase; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT REPEAT 33..65
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 66..98
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 99..131
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 193..448
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 454 AA; 51615 MW; AF9C0FB7903A9DB3 CRC64;
MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSSVV DMLIMRGARI
NVMNRGDDTP LHLAASHGHR DIVGKLIQCK ADTNAANEHG NTPLHYACFW GQDQVAEDLV
TNGAQVSICN KYGETPLDKA KPHLRELLRE KAEKLGQNLT KIPFKDTFWK GTTRTRPRNG
TLNKHAGVDY KQLSFLAKIN ENQSGELWQG RWQGNEIVVK VLKVRDWTTR KSRDFNEEYP
KLRIFSHPNV LPMLGACQSP PAPHPIIITH WMPYGSLYNV LHEGTNFVVD QTQAVKFALD
IACGMAFLHT LEPMIPRHYL NSKSNHKSID EDMTARISMA DVKFSFQCPG RMYSPAWVAP
EALQKKPEEI NRRSADMWSF AILLWELVTR EVPFADLSNM EIGMKVSLEG LRPTIPPGIS
PHICKLMKIC MNEDPAKRPK FDMIVPILEK MQDK
//
