ID A0A3B4ZPE5_9TELE Unreviewed; 1411 AA.
AC A0A3B4ZPE5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0000256|ARBA:ARBA00031556};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000003607.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000003607.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 144197.ENSSPAP00000003607; -.
DR Ensembl; ENSSPAT00000003682.1; ENSSPAP00000003607.1; ENSSPAG00000002800.1.
DR GeneTree; ENSGT00440000034289; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17735; BRCT_BRCA1_rpt1; 1.
DR CDD; cd16498; RING-HC_BRCA1; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 2.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PIRSF; PIRSF001734; BRCA1; 5.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 22..64
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1208..1293
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1314..1411
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 102..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1411 AA; 153809 MW; A0A97785D0BD8718 CRC64;
MKTPEATDVK KGISVLWETL QCPICLDLMT APVATKCDHQ FCKFCMMKLL DSSKQNRASC
PVCKAKITKR SLQESPGFQR LVAGLQDMIQ AYEHDTGTNY FTGVPQTEKH SSVTDAEHTK
HPHSVSSGDT PSTGLDNVES ADHEDLPRSN SSTIAAQNGF ARLMGLEDSA PLTTENEGLD
SGLGGAPPTS DKKTSSSTDN VDPAQTEVPE IVAKATPSHK TRSERKSVNS ENLCPILISE
ETEPQPSRKS SRKKRKRDLE PDKILEQKQK KSLEKVTEWL MKVPTEGGLE LEKPDDDADD
SDSSSSASTI DLKQSISDLI PKREERTRAL EDQVFGAVYK RERRGNKTFS PPLNVFVEPP
TPSEIQREED DLTPADGENN IEGDGEMIEE VNDTSSDIFK VVEQMEIREE NNTHVEDLNS
FPESDKNEGV DEVPCPVSDI VRQQPATKAK KRMDNPLQHV DSDLQEQAMA KAEGSEQKKT
DKRKGKNAKP EKGKPARVPK PLVLVGVQNG ETSPQTRSEE VQVQIETYPS SEDQETPVMR
SSRRSRRLQL FAEEVQEGRK KANMKAKVPE KKRSTSKKSE NPKGETLHNT TPEKDSVTKA
ATRNGCVFDE DIGGIENLES DERTSFVKPA ENVTAEVPNP ETVPEAGAAA ACVSLVSSSS
SPSDATVVGP TLEDDKPTNT VTNSVRLEAS VCETKCAETE NDEDKNDSEV DTEQLLRSFK
ATKRKSFHLG CPNVKRSRRS DKDNMQVTEA KEDRRDCSDA PKTSEATNQE ALKDTEKSSC
SDFISPSISP VQTRKAVAEK PDQVVVETSI PHSSCSDQDS AAGDLRSSLS SALSPNKVTK
SDRESSQLSV VPQIVDSGLR FTAVEYEEPN KAPNCSQITD SQLDCTARDA GKGNEIRDSL
ARNSAATVNY CSDNTAERIP IADSSLTPDD LLPPSVEIVH KATTKGPGSG EVSGHSSIKT
NPRKTRRAQR LESSSESDGS GSKEELPTLT QIFGTSARPS AVNQDQIESC QVACVTADAA
EPLSPDSVNS SQGSVDLFGT PDECDVPVND ISVSFESSQF SSEVLVTQQK IEMQKELVRL
EKLMALVSEV LQEKEESPAK ETHQGSRSTG TDAHKSHLCD RDAGQGSDGK HVPDAGRDLN
AGTSDGKGVT ERGGITETGL SVKGTGGSKM SGLASVAKTL KNCSSPSDGQ DDKENDSPPK
DGCKAKLVLV SSGLGPSEQI MVKKFAKRVG ARVVSQVTAD VTHIIMQTDE QLVCERTLKY
FLGIAGRKWV VGFQWITECF KQKKLLDESP FEVRGDVVNG SNHQGPWRAR TTDDSNLLMR
GFKICFQGPF TDMTTGEMEW MVELCGAAVV RDPLFLDSKQ KSHQLVIVQP RSDSSSSTYS
SLSRRATVVS RGWLLDTVAT YTLQNFNNYT T
//
