ID A0A3B4ZQ32_9TELE Unreviewed; 801 AA.
AC A0A3B4ZQ32;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Toll-like receptor 1 {ECO:0000313|Ensembl:ENSSPAP00000011013.1, ECO:0000313|RefSeq:XP_008291347.1};
GN Name=tlr1 {ECO:0000313|RefSeq:XP_008291347.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000011013.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000011013.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008291347.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR RefSeq; XP_008291347.1; XM_008293125.1.
DR AlphaFoldDB; A0A3B4ZQ32; -.
DR STRING; 144197.ENSSPAP00000011013; -.
DR Ensembl; ENSSPAT00000011206.1; ENSSPAP00000011013.1; ENSSPAG00000008389.1.
DR GeneID; 103365639; -.
DR CTD; 7096; -.
DR GeneTree; ENSGT00940000162201; -.
DR OrthoDB; 21383at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..801
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041074316"
FT DOMAIN 644..787
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 801 AA; 90448 MW; D569F2304D44AF30 CRC64;
MKLTPAFLWA AVMLVGLQRS ASSPDSTVNR SSQNLSAVPR DLPPAVEVLD LSCNHIHQLH
KGDFRNTTLL RILNVSWNGL EEIDAQTFLD TPLLEDLDLS HNSLKNLSGQ QYLLHTGNLL
VLNLAYNKIF SMTLGSEFSS LVKLERLTIG AKNISQGDFK NIAEVKLRIL TLSLEGELGY
EASSLTGVHT QKLQIAFSKN QIMDHDLVAD ALSLFDEVEM MNLTSGYKDL SMQLSEREEI
HTSHFDLTNL VIDWQDLTRF VNVVLRTSIS HLSASDVAIN HPPYTDTFVT PISKMKSFTA
RRATVNSFFF SQESVYNFFI NLPVKSVAIM ETSIIHMTCP TAQSPILQLD FSNCAISDSI
FSTVKGDKIV ECENLGNVKK LILGGNNFKN LQVLSNRTQH MMSLQHLDLS LNSITYDGLL
ECFWPPSITN MNLSSNSLTD SVFQCLPKGT ETLDLQNNQI SVVPPSIFKL ENLSSLNLNA
NRLRDLPVCN TFPILSELLL QSNSLHAPSV NRLESCPKLK TLDASHNPFT CTCALRHFIR
LPIKSKSKSQ TGIELLSWPL DYYCTYPEAV RNSTLKDIWI PEISCNVGLL SATILVPAVA
LILTVVILCH RLDVPWYIGM VWQWTRAKHR ARMQHVRPED LVDVEFHAFV SYSQHDADWV
HNSLLPNLEG PAGELRICHH EKNFVPGKTI IENIISCVEK SRRSVFVLSA HFVKSDWCHY
ELYFACHQRL SRGLDSIVLV LLEPLPQYLI PSKYYQLKSM MSRHTYLEWP QDRAKHRLFW
ANLRAALQAD LPNAPVAEIQ E
//
