ID A0A3B4ZR01_9TELE Unreviewed; 643 AA.
AC A0A3B4ZR01;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neuroendocrine convertase 2 {ECO:0000313|RefSeq:XP_008277756.1};
DE SubName: Full=Proprotein convertase subtilisin/kexin type 2 {ECO:0000313|Ensembl:ENSSPAP00000010660.1};
GN Name=pcsk2 {ECO:0000313|RefSeq:XP_008277756.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000010660.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000010660.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008277756.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
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DR RefSeq; XP_008277756.1; XM_008279534.1.
DR AlphaFoldDB; A0A3B4ZR01; -.
DR STRING; 144197.ENSSPAP00000010660; -.
DR Ensembl; ENSSPAT00000010839.1; ENSSPAP00000010660.1; ENSSPAG00000008093.1.
DR GeneID; 103355664; -.
DR CTD; 5126; -.
DR GeneTree; ENSGT00940000156965; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016486; P:peptide hormone processing; IEA:UniProt.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..643
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041074239"
FT DOMAIN 465..601
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 171
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 212
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 388
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 643 AA; 71262 MW; DF4B6AB5F17755C1 CRC64;
MRGSPRHGTA VGFTVLLNAL LLLLATQATE GVLTDHLLVQ LHEDAQDEAH QLATQHGFQS
ARKLPFGEGL FHFYPQDTSK RRSKRSAHSR QRLQKDRRVK NVFEQEGFSR QKRGYRNIND
IEVNMSDPLF TKQWYLINTG QADGTPGLDL NVAEAWQLGY TGKGVTIAIM DDGIDYLHPD
LASNYNADAS YDFSSNDPFP FPRYTDDWFN SHGTRCAGEV SAAANNNICG VGVAYNSKVA
GIRMLDQPFM TDIIEASSIS HMPQVIDIYS ASWGPTDDGK TVDGPRELTL QAMADGVNKG
RGGKGSIYVW ASGDGGSYDD CNCDGYASSM WTISINSAIN DGRTALYDES CSSTLASTFS
NGRKRNPEAG VATTDLYGNC TLRHSGTSAA APEAAGVFAL ALEANPNLTW RDMQHLSVLT
SKRNQLHDEV HQWRRNGVGL EFNHLFGYGV LDAGGMVKMA KEWKTVPERF HCVAGSIQET
HKIQSGNKLL LAINTEACQG KDNFVRYLEH VQAVITVNAS RRGDLNINMT SPMGTKSILL
SRRPRDDDSK VGFDKWPFMT THTWGEDPRG TWVLEVGFQG EEPQRGVLKE WTLMLHGTQS
APYIDQIVRD YQSKLAMSKK EELEEELDEA VERSLKSLLS KNN
//
