ID A0A3B4ZSG8_9TELE Unreviewed; 399 AA.
AC A0A3B4ZSG8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Tissue-type plasminogen activator-like {ECO:0000313|Ensembl:ENSSPAP00000009144.1, ECO:0000313|RefSeq:XP_008295815.1, ECO:0000313|RefSeq:XP_008295816.1};
GN Name=LOC103369012 {ECO:0000313|RefSeq:XP_008295815.1,
GN ECO:0000313|RefSeq:XP_008295816.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000009144.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000009144.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008295815.1, ECO:0000313|RefSeq:XP_008295816.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR RefSeq; XP_008295815.1; XM_008297593.1.
DR RefSeq; XP_008295816.1; XM_008297594.1.
DR AlphaFoldDB; A0A3B4ZSG8; -.
DR STRING; 144197.ENSSPAP00000009144; -.
DR Ensembl; ENSSPAT00000009308.1; ENSSPAP00000009144.1; ENSSPAG00000006973.1.
DR GeneID; 103369012; -.
DR CTD; 100008445; -.
DR GeneTree; ENSGT00940000164426; -.
DR OrthoDB; 4629979at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR GO; GO:0031639; P:plasminogen activation; IEA:Ensembl.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24264; TRYPSIN-RELATED; 1.
DR PANTHER; PTHR24264:SF38; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Digestion {ECO:0000256|ARBA:ARBA00022757};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363034};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..399
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041074233"
FT DOMAIN 33..106
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 140..386
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 399 AA; 44441 MW; 2FDC8B2F39B85A53 CRC64;
MNLFAIIAVL AAFSVNVVFS QRWSKKKVGK EELCRSGDGS SYRGFINRSA IGRKCLNWNR
QKHLKGASKG LGDHNYCRNP DYSLMPWCLV RRRSRIVREF CDIPRCSNTG SRPTVKPQPQ
PTMDTEQSCG ERVERRMNKI VGGSFTPIES HPWVAAIFHK RYGFLCGGSL ISPCWVLTAA
HCFTDGENTK IPHLSVYLGK SAINDTDVDK EQQFFVEKLI IHQKYNDSNY DSDIALVKIK
SRNATTHGGC AVRSPTVRTV CLPPLHTQLP AGFSCSIAGF GKEKFESPRF SQYLKQADVK
LLSRAECTSG LQYGSRITDN MFCAGSPSWS TDACKGDSGG PLVCEASGRM FLFGVVSWGE
GCGWMNKPGV YTQVTNYNKW IAAKTGLTKY TRGLMYPQK
//
