ID A0A3B4ZSZ4_9TELE Unreviewed; 402 AA.
AC A0A3B4ZSZ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Cytohesin-2 {ECO:0000256|ARBA:ARBA00040245};
DE AltName: Full=PH, SEC7 and coiled-coil domain-containing protein 2 {ECO:0000256|ARBA:ARBA00042728};
GN Name=CYTH2 {ECO:0000313|Ensembl:ENSSPAP00000004837.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000004837.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000004837.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; A0A3B4ZSZ4; -.
DR Ensembl; ENSSPAT00000004933.1; ENSSPAP00000004837.1; ENSSPAG00000003683.1.
DR GeneTree; ENSGT00940000160074; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF343; CYTOHESIN-2; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 52..244
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 262..378
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 16..50
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 402 AA; 46759 MW; CF0C7948588FF65D CRC64;
LETVPVDLSP EERSELEDIR RRKGVLLQEI QRLREELREA ILEVEGLETS TEGSKTLQKS
RHVAMGRKKF NMDPKKGIMF LVENELLRHT PEDIAQFLYK GEGLNKTAIG DYLGERDDFN
IKVLQAFVDL HEFTDLNLVQ VFSGQQTRPF LWSFRLPGEA QKIDRMMEAF AQRYCHCNPG
VFQSTDTCYV LSFAIIMLNT SLHNPNVRDK PGVDRFISMN RGINEGGDLP EELLRNLYES
IKNEPFKIPE DDGNDLTHTF FNPDREGWLL KLGGRVKTWK RRWFILTDNC LYYFEYTTDK
EPRGIIPLEN LSIREVEDPR KPNCFELYIP NNRGQLIKAC KTEADGRVVE GNHMVYRISA
PTPEEKDEWI HSIKSAVSVD PFYEMLAARK KRISLKKKEE QP
//
