ID A0A3B4ZU30_9TELE Unreviewed; 422 AA.
AC A0A3B4ZU30;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Homeobox protein Nkx-2.6-like {ECO:0000313|Ensembl:ENSSPAP00000011291.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000011291.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000011291.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Nanog homeobox family.
CC {ECO:0000256|ARBA:ARBA00043992}.
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DR AlphaFoldDB; A0A3B4ZU30; -.
DR STRING; 144197.ENSSPAP00000011291; -.
DR Ensembl; ENSSPAT00000011490.1; ENSSPAP00000011291.1; ENSSPAG00000008534.1.
DR GeneTree; ENSGT00670000098076; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24327:SF72; HOMEOBOX PROTEIN NANOG2-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 212..272
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 214..273
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 90..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46247 MW; 9161DB816D6CC5DE CRC64;
MADLKNQINF NYHCPYYSYA FGIMYQSGPE QNHGNLSGWS DSTVADLGNS NPGVTQAYYA
AESPPHSPER HAVNGHGHYQ GSGVVYLGDT QPGSLLVTGP PQSAYDAREN EVGRAGSDTM
SDTEVRTSPD SWSSSSSSRE GSLPHADPAT WAKKDLHQET SRVSPGANRT VSSSLIEEPR
AFPVPEGNLA NNNTSAAPIT APKKPGTPGM NNPRGKVRTA FSESQMNTLV HRFSVQRYLT
PAEMKNLAEL TGLTYKQVKT WFQNRRMKLR RHQKDTSWVS ERYSINKESM FSTIPPYIPP
YQGEARPQLR EHYNQHVMEA AFKKTTPQNL AFYLAAMGTG SPGYPAWSST SPQAAAPNRP
QMTSWSMPQG VGNYEYNPSP FNLAPVAALN NFGHDPSFEN NDGVPVNTQS SLNAAMAHNT
GQ
//
