ID A0A3B4ZUC7_9TELE Unreviewed; 957 AA.
AC A0A3B4ZUC7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Integrin subunit alpha 4 {ECO:0000313|Ensembl:ENSSPAP00000011401.1};
GN Name=ITGA4 {ECO:0000313|Ensembl:ENSSPAP00000011401.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000011401.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000011401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B4ZUC7; -.
DR STRING; 144197.ENSSPAP00000011401; -.
DR Ensembl; ENSSPAT00000011604.1; ENSSPAP00000011401.1; ENSSPAG00000008620.1.
DR GeneTree; ENSGT00940000158443; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0043114; P:regulation of vascular permeability; IEA:Ensembl.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF78; INTEGRIN ALPHA-4; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 5.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 28..957
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5017103203"
FT REPEAT 32..94
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 148..200
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 256..316
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 318..376
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 380..442
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 427..584
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 592..729
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
SQ SEQUENCE 957 AA; 105814 MW; 47C3BACC21ADC1B2 CRC64;
PLLSERYSLR CSLVLVLLLV QVHPAAGYSL DQDHSLEFSG PSSSMFGYSV LLHRHKSHSW
LVVGAPVANS SYSPSVHSPG AVYRCNITAE HRRYVLTCGK TCEAESDHQW LGVSLSRQPG
DNGGHVLTKI YQSNNAPLFS SDFSSFKQYH QRKFGEDYGS CQAGISNFLT EDLIIMGAPG
TSYWTGSVLV YNTSSRGMSV YLDDENGAVS FGSYLGYSVG AGHFLSPLSV EVVGGAPQYN
QKGKVFIFTV DDNMLRVVSV VSGKELGSYF GSSVCVVDLN SDGLSDLLVG APMATGVTRE
EGRVHVYINQ GQAKLLEAEF QLSGSDAYAA RFGETIADLG DLDDDGYPDV AVGAPQEDDL
RGAVYIYNGR KEGISPTPSQ RITGSTLGHD LRMFGQSLSS GIDIDDNGYQ DVAVGAFLSD
SAVVLRTRPV IQVKASLTLP EQIDQRVALC HDHKTPTVCL NVTICFSVKS RRFRGPIDLQ
YNLTADLLHK PTFPHRFYFH GNGSSNSTKG HLRARQGHLM CKTHVAYQRK DVRDIFTPVQ
FEVSYSLKDT NTHRASSKTF PALKPILQQS AGHHNTITNQ TWFARSCYLV NCSTNMQLST
KLVLPHQQRY FALGSGQTIM LKTSVLNSGD DAFLPKLTLR FPNNIHYIKV LQNEENMVSC
DVIQEVNTTT AGVDCSVTSL RLPAHSQLNI SFLLDVNQSS TAGNISIHVN TYSDNYEREE
YLHDNSMRLV LPLKYGINVN IHGFVTPTSF VIGDEDLIPA SCYSERFNYT YKVGHKKRSY
SCVHSVCLQS SQGVCSISDT TVSVNEDCDV PQASFIKQLV FFFSPTSTRR MFCGRGDHLC
ERLVCRLGNL EVGRDATIKL EISLNPAVLL QAPGRHGIML LESTAMMSSP RNDSNTIVIQ
DQPIAQQHKL LFLFHVSVVL CVCQAGFFKR DLQKKQEEFN RDSWDYVPKQ NKRESTT
//
