ID   A0A3B4ZWK8_9TELE        Unreviewed;      1056 AA.
AC   A0A3B4ZWK8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Sortilin related VPS10 domain containing receptor 2 {ECO:0000313|Ensembl:ENSSPAP00000012675.1};
GN   Name=SORCS2 {ECO:0000313|Ensembl:ENSSPAP00000012675.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000012675.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000012675.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   AlphaFoldDB; A0A3B4ZWK8; -.
DR   Ensembl; ENSSPAT00000012890.1; ENSSPAP00000012675.1; ENSSPAG00000009512.1.
DR   GeneTree; ENSGT01030000234563; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF9; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2; 1.
DR   Pfam; PF18911; PKD_4; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00089; PKD; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 1.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           36..1056
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017446162"
FT   TRANSMEM        1032..1052
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          759..829
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          37..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1056 AA;  118258 MW;  B950BC9ECEF63BED CRC64;
     MAPLRPEEPV SAAAHLCVFL LTTSAWMALP GPVRCSSGAL NRRGGEDRTL DMGGGEGGSP
     PGLQTDVDEE GAGSSPRFRR ALSWDKQMSL LSSSFVLKGD ATHNQAMVHW TGENSSVILI
     LTKYYHADST KVLESSLWRS TDYGTTYTKL NLMPGTTIVV TSFYICPTNK KKVVLVGSSI
     NERDQMLFIS TDEGSSFQRQ SIAFTPETLV FHPKEEDKLL AYCKEGRLFA STDLGRKWTL
     LQERVTKDKV FWSVSGVDVD PDLVHMEMQD TSGGYLYVTC LIQNCSDKMV TAQFLGKIDH
     NSLLVQDDYI FVKVTTGNRT KHYVSYRRNE FVQMRFPKYA LPKDVQIVST DENQVFLALQ
     EWYQSDTYNL YQSDPQGVYY SIVLENVRST KQPEENVLID ILEVRGIKGV FLANQKIDGK
     VTTLITYNKG RDWEPLAPPT TDMNGKPVSC KAPDCHLHLH LRWADNPYVS GTVHTKDSAP
     GLIMGAGNLG SKLVEYKEEM YITSDCGKTW RQVFEEEHHI LYLDHGGVIV AIKDTSIPLK
     ILKFSIDEGR TWSVHNFTST SVFVDGLLSE PGDETLVMTV FGHISYRSDW ELVKVDFRQS
     FPRQCTESDY ESWQLTDLQG EKCIMGQERT FRKRKDTAFC IKGKSYISAL TNKSCQCTEK
     DFNCDYGFER SHTEGERCFA DFWHDPDSPP EDCHLGQNYE SSTGYRKVIS NICDGGLNKQ
     QSTKQHSCPL LPPKGLQVGI KGQMLAVAPG DDITFIVHQE QGDTSSTKYQ VDLGDGVRAI
     YQNLTVTDEP IQHRYENPGV YKVTVKAENM AGHDEATMYI QVTAPLQEVH LEVVPIAGRN
     HEVNLTAIVL PTEANMTVFY WWIGDSLRPT LTLRNSLLTR FPDTGEVSVT VQASNGRSMV
     QDTRTVRVYD NFQVVPLSFS RNLDRFNPNI PEWRDDIGQV VTKILAKITG VPQESLVTVV
     KPGLPTTADL YVLPLDSKPA KRSMFVDKRI PAIMQAFSDN NVSFVVRGGL QVLVMLADPN
     AGYHGAAGSP GVWALAVIFL ISIIATGSFI LYKFKR
//