ID A0A3B4ZWU0_9TELE Unreviewed; 2290 AA.
AC A0A3B4ZWU0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000012760.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000012760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR STRING; 144197.ENSSPAP00000012760; -.
DR Ensembl; ENSSPAT00000012976.1; ENSSPAP00000012760.1; ENSSPAG00000009547.1.
DR GeneTree; ENSGT00390000010427; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 1734..1914
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 128..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1941..2000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2136..2189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1693..1720
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 128..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1941..1968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1978..1993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2166..2183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2290 AA; 257283 MW; 1D2972358795ECFC CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LYNGRIAEEV TCLLGCRDEN
LASQLAHGLN QVSTEHIELK DNLGSDEPEG DAPLLLQTML ARNPGIFREK SMETNTYVMQ
QPMVPPFKMT QNSMHSPAQS ANFQPAAISP NPSSRFVAPQ TGSSSRYMGQ QNSPVPSPYT
PQSPAPGYIQ QYPHQQPPSY NQHQQIQQGE CICVSGSRPV ILQLPPPYAP SPRDGGPDQK
QQLQQRKKTP AVKEEKDMYD IVSSPNKDST KLTLKLSRVK SNESDPPGKI LDALDLGSPS
LLQFHNKPLK KRKQDSFPLE PGAGGPGGPT GAPGSGSTGG GNAGKLTPQE ATAAGNGASR
PPLMVSIDLQ QAGRADGQLD PCLAAPIPAL EAQRWPEEPA SGPAAVEGSD TALRLKPDGR
QDGSKAASSA SGAKLPDSFP AHLLGGHSGA LKNFQIPKIN RDKDGSGSTE SQMWGQPKVK
LERLGLVKDF EKRPKPVVVL KKLSIDQIQR IIRHSKSGKN RISSGKSGKS GMDPAVLKEL
PPELLAEIES TMPLCERVKM NKRKRSTVNE RPKYAEVSSD DDFDRQRREK DRAWEFEERE
RRGSGEHRKS GHRDGRRGSG SRYRDSSEED SPPPSMSEIA RKMKMKEKQK KRKAYEPKLT
QEELMESSTF KRFLASIDNI LENLEDVDFT AMDDDEIPQE LLLGKHQLNE LGSESAKIKA
MGISSRIPSD KLVKLLNILE KNIQDGSKLT TMMNHDHDAE DEERLWRDLI MERVTKSADA
CLTALNIMTS AHMPKAVYIE DVIERVLQYT KFHLQNTLYP QYDPVYRVDP HGGGMLSSKA
KRAKCSTHKQ RVIVMLYNKV CDIVSNISEL LEIQLLTDTT ILQVSSMGIT PFFVENVSEL
QLCAIKLVTA VFSRYEKHRQ LILEEIFTSL ARLPTSKRSL RNFRLNSSDQ DGEPMYIQMV
TALVLQLIQC VVHLPSDKDV FEEYETKVDQ DVLITNSYET AMRTAQNFLS VFLKKCGSKQ
GEEDYRPLFE NFVQDLLSTV NKPEWPAAEL LLSLLGRLLV HQFSNKQTEM ALRVASLDYL
GTVAARLRKD AVTSRMDQRS IDRNDETQQL QKALLDYLEE NAETDASLVF ARKFYIAQWF
RDATTEAEKS MRNQNPKDED SSDGPQHAKD LETTGEIMQR AEKRKKFLRN IIKTTPAHFT
TLKMNSDTVD YEDSCLIVRY LASMRPFAQS FDIYLTQILR VLGESAIAVR TKAMKCLSEV
VAVDPSILAR SDMQRGVHGR LMDNSTSVRE AAVELLGRFV LSRPQLTEQY YDMLIERILD
TGISVRKRVI KILRDICLEQ PTFSKITEMC VRMIRRVNDE EGIKKLVNET FQKLWFTPTP
AHDKETMTRK ILNITDVVAA CRDTGYDWFE QLLQNLLKSE EDASYKPAKK ACVQLVDNLV
EHILKYEESL AENKGVNSTR LVACITTLYL FSKIRAQLMV KHAMTMQPYL TTKCNTANDF
MVICNVAKIL ELVVPLMEHP SETFLATIEE DLMKLIIKYG MTVVQHCVSC LGAVVNKVTH
NYKFVWACFN KFYGALNKLK IQHQEDPNST TLVANKPFLL RSLFTVGALA RHFDFDLEEF
KGTNKVVIKE KVLELLLYFT KHEDEEVKTK AIIGLGFLVI MHPSQMFVPE VKSLYNGILA
DASSSINLKI QILKNLQTYL QEEDTRMQEA DREWKKLSKQ EDLKEMGDIS SGMSSSIMQL
YLKQVLEAFF HTQSSVRHFA LNVIALTLNQ GLIHPVQCVP YLIAMGTDPE PSMRNKADQQ
LVEIDKKYTG FIHMKAVAGM KMSYSLQQAI ASSRKAIIRG FRQDETHSAL CSHLFTMIRG
NRQHRRAFLI ALLNLFDDSA KTEVNMLLFV ADNLACFPYQ SQEEPLFIMH HIDITLSVSG
SNLLQTFKEL LLKEPRRKEK KVKKEWKNTS DGEDEEEKMN CDSPRSDDEE NGNSDEDNDD
DVVRRPKNSE SESDLDDLDV EDAEKVMRLL PDNPTGLLDF ANAVQGILLL LVLKQHLKNQ
YGFSDSKIQK YSPTESAKVY DKAVNRKSNV HFHPRQTIDF ISNNMAHASL TDDVKKRIVK
QYLDFKVLME HLDPDEEDEE GEASASANIR NKAINALLGG SGPMSGPSPR NQAGPETDDD
DSDGDERTPG SSRRSRRAGD SSDPGRMSET VDAMDVIALC CPKYKDRPQI ARVIQKTSSG
YSIHWMAGSY SGPWAEAKKR DGRKLVPWVD TIKESDIIYK KIALTSNHKL SNKVVQTLRS
LYAAREGGAS
//
