ID   A0A3B5A515_9TELE        Unreviewed;       800 AA.
AC   A0A3B5A515;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN   Name=AMPD3 {ECO:0000313|Ensembl:ENSSPAP00000016398.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000016398.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000016398.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B5A515; -.
DR   STRING; 144197.ENSSPAP00000016398; -.
DR   Ensembl; ENSSPAT00000016661.1; ENSSPAP00000016398.1; ENSSPAG00000012364.1.
DR   GeneTree; ENSGT00950000183011; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF2; AMP DEAMINASE 3; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..800
FT                   /note="AMP deaminase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017325064"
SQ   SEQUENCE   800 AA;  92517 MW;  AEBA73C1E8A8E39C CRC64;
     MAALPLFLSL LFSRLWLLRK MRRGDTPLLK QQSSPCLGKN MPRQFPKVTL SEAEEETQLR
     AEKVYASALK EEDNKDALSM FTVPEDCPIG LQQAKEHELL KELAEQQSEE SAKRRKSLKM
     IRSQSLSLQI PVNTDWPRSV AATPYLSPSS TCSSVPESCP DYQRVTISGD CCAGVTVEDY
     EQAARSLFKA LLIREKYSKL AYHRFCRTTS QFLRSAENMR WSEEDEVLPD MWPCPADGED
     PYRMDNTPEN LNYELKMKDG IVYVYDNEEA LRKQQAHDLP YPDLETFAID LSHVLAMIAD
     GPTKTYCHRR LNFLSSKFFL HEMLNEMAEL KELKSVPHRD FYNVRKVDTH IHAAACMSQK
     HLLTFIQTTY KTDANRVVLE NAGQKMTLQQ VFHSLNMDPY DLTVDSLDVH AGRQTFHRFD
     KFNSKYNPVG ASELREIFLK TDNLINGEYF ARIIKEVAHD LEESKYQHAE PRLSIYGRSP
     DEWDSLSEWF IHQKVYSPNM RWIIQVPRIY DIFKAKRLVP NFAKMLENIF LPLFKATVNP
     QKHKELHVFL KYVSGFDSVD DESKHSDHMF SFRSPKPEQW TADVNPPYSY YIFHMYANIM
     VLNNLRKERG LSTFQFRPHC GEAGSITHLV SAFLTTDNIS HGLNLKKSPV LQYLYYLAQV
     PIAMSPLSNN SLFLEYSKNP LREFLHKGLC VSLSTDDPMQ FHYTKEPLME EYAIAAQLWK
     LSTCDVCEIA RNSVLQSGLS HRDKKHFLGV NYLKDGHEGN DIRRTNVAQI RMAYRHETLC
     NELSFIVDAV KSDAVNGQYE
//