ID   A0A3B5A6F5_9TELE        Unreviewed;       790 AA.
AC   A0A3B5A6F5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=RAS protein activator like 1 {ECO:0000313|Ensembl:ENSSPAP00000015916.1};
GN   Name=RASAL1 {ECO:0000313|Ensembl:ENSSPAP00000015916.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000015916.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000015916.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B5A6F5; -.
DR   STRING; 144197.ENSSPAP00000015916; -.
DR   Ensembl; ENSSPAT00000016173.1; ENSSPAP00000015916.1; ENSSPAG00000011944.1.
DR   GeneTree; ENSGT00940000158715; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR   CDD; cd13369; PH_RASAL1; 1.
DR   CDD; cd05135; RasGAP_RASAL; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR037776; RASAL_RasGAP.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF3; RASGAP-ACTIVATING-LIKE PROTEIN 1; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00107; BTK; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00432}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..790
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017212289"
FT   DOMAIN          1..98
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          109..228
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          298..506
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          558..665
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   790 AA;  89630 MW;  65F86C82F2580900 CRC64;
     MLCLSLSYFF LVLLRSGTSD PYCIVKVDNE VVARTATVWK NLNPFWGEEY TLHLPMGFHS
     LSFHVMDEDT IGHDDVIGKI TLSKEAIGSQ AKGLDSWLNL TRVDPDEEVQ GEIHLSLALL
     KDAEKLSLRC QVIEARDLAP RDISGTSDPF ARVLFDNHSA ETSIIKKTRF PHWGETLELE
     LDPEELSVDG TVTVEVWDWD MVGKNDFLGK VEIPFACLHK TPLLEGWFRL LPLGNNEVDA
     GGKLGALRLK VRLVEDRILP SMYYQPLIDL LVESVISPAE VEDSSALTML EDVTTVESRQ
     DVAMTLVKIY LGQGLVVPFL DYLNTREVNH TSKIKEKTGL EYECMSELMR IAVGMLYLHE
     VLKPIINRIF DEKKYIELDP CKIDLNRTRR ISFKGAVSEA EVRDSSVEML QSYLTSIIES
     IVGSVDQCPP VMRVAFKQLH KRVEEQFTEP ENEDVKYLAI SGFFFLRFFA PAILTPKLFQ
     LRDQHADTRT SRTLLLLAKA LQSVGNLGLQ LGHGKEQWMA PLHPIILRSV ASVKDFLDKL
     IDIDHDVVPQ RAVFMPSVTV KEGYLNKHKA EGPQLLSRFA FKKRYFWLTS ETLSYAKTPD
     WQVRSSIPIQ CVCAVERVDE NAFQQQNVMQ VITQDNDGQL HTMYIQCKNV NELNQWLSAI
     RKVSIYNERM LPSFHPGAHR SGKWTCCLQA DRAGCSRTHS AVTLGDWSDP LDPDVETQTI
     FKQLLQGRDK LRSVPVKSSA LMQLIYRTLE VYPGQSVAAR LLAVIEDLEQ AHTTFQHREK
     EDATSVILNP
//