ID   A0A3B5A6R3_9TELE        Unreviewed;       557 AA.
AC   A0A3B5A6R3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Uncharacterized LOC103374332 {ECO:0000313|Ensembl:ENSSPAP00000009367.1};
GN   Name=KCNK4 {ECO:0000313|Ensembl:ENSSPAP00000009367.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000009367.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000009367.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC       ECO:0000256|RuleBase:RU003857}.
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DR   AlphaFoldDB; A0A3B5A6R3; -.
DR   STRING; 144197.ENSSPAP00000009367; -.
DR   Ensembl; ENSSPAT00000009532.1; ENSSPAP00000009367.1; ENSSPAG00000007112.1.
DR   GeneTree; ENSGT00940000160310; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003976; 2pore_dom_K_chnl_TREK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003:SF30; POTASSIUM CHANNEL SUBFAMILY K MEMBER 4; 1.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01499; TREKCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003857};
KW   Ion transport {ECO:0000256|RuleBase:RU003857};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003857};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT   TRANSMEM        6..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        86..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        165..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        193..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        224..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          81..136
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          177..248
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   REGION          349..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..439
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..510
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..541
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..557
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   557 AA;  61464 MW;  3E76CB51C3E28FCE CRC64;
     MRCSTLTTLL TGVTLYLVMG ALVFLTLETP GESLAHKNLL QTQEDFLSNN SCVTESDFDT
     LGLVSAVKAG LDVSNLPSNL TTRWDMASAI FFCGTIITTI GFGNLSPRTW YGQLFCVCYA
     LVGIPMFGIL LAGVGDHMGT VLRRAVAKIE TLFLKRKVRP TTVRVISAVL SILIGCLIFL
     AVPTVVFHQV EDWSFLESLY FVVITLTTVG FGDYVPGGRI FKPLVLLWIV FGLAYFASIL
     TMIGNWLRVL SKRTRAEMEE LRAHATDWTQ NMDFRIPNPL EFNDPFLLQR RRWKRSERRR
     IRRGAQGTLG YLVRGGSENG HLPNRWAGLS SSMTQLEAHS SLERAVVAKS KPRGSAAGGI
     TSQRAALGQR TEPAVGLQRP GRSFPHMLAR SFSVPVARST LELDSAGKDK PIPAENCESV
     VNNSHKHAPA PSFPSHSSRL APSHHPILPP SPHVCTASSA GCQLLDFFGE NLAYIDESSD
     TLSDRAQSTT SEERRRRIRK PKKRSMRRQL SHRWSPLQVR RPHTDMSPPS NPPPPPPDSS
     LSDLPQSGNQ IDSVSAL
//