ID A0A3B5A7U3_9TELE Unreviewed; 746 AA.
AC A0A3B5A7U3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Iron-sulfur clusters transporter ABCB7, mitochondrial {ECO:0000256|ARBA:ARBA00041016};
DE AltName: Full=ATP-binding cassette sub-family B member 7, mitochondrial {ECO:0000256|ARBA:ARBA00042945};
GN Name=abcb7 {ECO:0000313|RefSeq:XP_008282600.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000016830.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000016830.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008282600.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O =
CC (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:67028, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167627,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036789};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67029;
CC Evidence={ECO:0000256|ARBA:ARBA00036789};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
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DR RefSeq; XP_008282600.1; XM_008284378.1.
DR AlphaFoldDB; A0A3B5A7U3; -.
DR STRING; 144197.ENSSPAP00000016830; -.
DR Ensembl; ENSSPAT00000017093.1; ENSSPAP00000016830.1; ENSSPAG00000012679.1.
DR GeneID; 103359151; -.
DR CTD; 22; -.
DR GeneTree; ENSGT00940000156281; -.
DR OrthoDB; 2876209at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:1990748; P:cellular detoxification; IEA:Ensembl.
DR GO; GO:0010312; P:detoxification of zinc ion; IEA:Ensembl.
DR CDD; cd18582; ABC_6TM_ATM1_ABCB7; 1.
DR CDD; cd03253; ABCC_ATM1_transporter; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF402; IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840,
KW ECO:0000313|RefSeq:XP_008282600.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 133..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..429
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 465..699
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 706..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 82219 MW; 30B258CFA7766C88 CRC64;
MAPMLAPLKC GFHIQRRKLA FLIRQTSSYH VWNKSRTENE TVRKRQSTYV LNSFPHLRTA
TWGTNGSENS RQILEAAKHL QVTNKRTCWH GHAGGGLSAD PKNVLNEVNS TQILSAMLSY
VWPKDRPDLR ARVAISLGLL AGAKITNVMV PFMFKYAVDE LNQMSGHMLN LNDAPSTVAT
MATAVLIGYG VSRACAAAFN ELRNTVFGKV AQSSIRRIAK NVFLHLHNLD LGFHLSRQTG
ALSKAIDRGT RGISFVLSAL VFNLGPTVFE MGLVSAILYY KCGGQFAAVA VGTLSAYTLF
TILITQWRTR FRIEMNKADN EAGNAAIDSL LNYETVKYFN NEKYEAQRYD GFLKIYEASS
LKTTSTLAML NFGQSAIFSV GLTGIMVLAS KGIAAGTMTV GDLVMVNGLL FQLSLPLNFL
GTVYRETRQA LIDMHTLFTL LSVDTKIKER DLAPPLTIAP QDATIRFEDV YFEYLEGQKV
LNGVSFEVPA GKKVAVVGGS GSGKSTIVRL LFRFFEPQRG NIYIAGQNIR DISLDSLRKA
LGVVPQDAVL FHNTIFYNLQ YGNINATPEE VYQVARLAGI HDAILRMPHG YDTQVGERGL
KLSGGEKQRV AIARAILKNP PILLYDEATS SLDSITEENI LSSMKGMVKD RTSMFIAHRL
STIVDADEII VLNEGKVAER GTHNALLSIP GSLYGDLWNA QNSKILNNST NPPDPPAERL
SQKEEERKKL QEEILNSVKG CGNCSC
//
