ID A0A3B5A896_9TELE Unreviewed; 1603 AA.
AC A0A3B5A896;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000256|ARBA:ARBA00016709};
DE AltName: Full=Cyclic nucleotide ras GEF {ECO:0000256|ARBA:ARBA00031545};
DE AltName: Full=Neural RAP guanine nucleotide exchange protein {ECO:0000256|ARBA:ARBA00032021};
DE AltName: Full=PDZ domain-containing guanine nucleotide exchange factor 1 {ECO:0000256|ARBA:ARBA00030673};
DE AltName: Full=RA-GEF-1 {ECO:0000256|ARBA:ARBA00029925};
DE AltName: Full=Ras/Rap1-associating GEF-1 {ECO:0000256|ARBA:ARBA00031980};
GN Name=RAPGEF2 {ECO:0000313|Ensembl:ENSSPAP00000017638.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000017638.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000017638.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, perinuclear
CC region {ECO:0000256|ARBA:ARBA00004556}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Late endosome
CC {ECO:0000256|ARBA:ARBA00004603}.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR STRING; 144197.ENSSPAP00000017638; -.
DR Ensembl; ENSSPAT00000017912.1; ENSSPAP00000017638.1; ENSSPAG00000013176.1.
DR GeneTree; ENSGT00940000156418; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR PANTHER; PTHR45161:SF2; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 3..50
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 262..327
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 394..508
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 512..582
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 748..834
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 859..1086
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 167..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..223
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1266..1285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1449..1463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1465..1481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1603
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1603 AA; 177860 MW; 3F40FF9311533ED5 CRC64;
MEALSNLREH QLRIMCETVR YERHEANEVL YYPDDIGSCW YILLSGSVFI KESMFLPRSS
FGKRSAGSLR RGCECIVLEP SEMIVVDYMD ENEEYFQRQA SHRQSRRRFR KINQKGERQT
IIDTVDPYPT GKPPIARGYH TECNKPQLPA DFSRLHLADG LHPQVTHVSS SHSGCSITSD
SGSSSLSDIY QATENEPGDM DLSGLPETAV DSEEDDDEED IERASDPLMS RDIVRDCLEK
DPMDRTDDDI EQLLEFMHQL PAFANMTMSV RRELCAVMVF AVVERAGTIV LNDGEELDSW
SVILNGSVEV TYPDSRTEIL CMGNSFGVSP TMEKEYMKGV MKTKVDDCQF VCIAQQDYCC
ILNQVEKNMQ KVEEEGEIVM VKEHRELDRT GTRKGHIVIK GTPERLTMHL VEEHSVVDPT
YIEDFLLTYR TFLSSPMVVG KKLLEWFHDP SLRDKVTRVV LLWVNNHFND FEGDPAMTHF
LEEFENNLEK EKMCGHLRLL NIACAAKAKP RLVTLTKPSR DSPLAFSLLG GQEKGFRIFI
DAVDPGSKAA EVGLKRGDQI LEVNGQNFEN VQLSKANEIL KNNTHLSITV KTNLLVFKEL
LTRPEHDHDL DGEEEHDRKN GAPHLPKIGD IKKASRYSIP DLAVDVEQVM GLEKVSKKAK
TNTVGGRNKL KKIFDKTLTS ILPPKPYNDV CVGQSQDDSI VGMKQSKQIP PALPVSGNLS
SSNPDLLQSH HRILDFNNQP VPVTLNMSDQ VLRVFKADQQ SRYIMIGKDT TAKEVVAQAI
REFALTAAPE AYSLCEVSVT PEGVIKQRRL PDQLSKLADR IQLSGRYYLK SNMETETLCS
DEDAQDLLRE GQISLLQLST VEVATQLSMR AFELFCAIEP TEYIDDLFKL RSKTGSASLK
RFEEAINHET FWVATEVTRE PNQLKRMKTV KHFIKIALHC RECKNFNSMF AIISGLNLAP
VSRLRGTWEK LPSKYEKLFG DLQDLFDPSR NMAKYRNVLN NQNLQPPIIP LFPVIKKDLT
FLHEGNDSKV DGLVNFEKLR MIAKEIRHVG RMASVNMDPA LMFRTRKKKW RSLGSLSQGS
ANAAVLDVTQ TGGHKKRVRR SSFLNAKKLY EDAQMARKVK QYLSNLSLET NEESLQTLSL
QCEPSISTLP KNAGGKRPDT SPVVPRAASQ QRGQLAKGNQ ALQVPAVALY PSRKKVPVKD
LPPFGTSSPQ SLKKILSLSE EGSERHRRQP EDTVSNASSQ LSSPPTSPQS SPKKGYNRMG
DAYSDSGHSE ISSRSSLVSN SSFDMAQEER RLRHSGGVGE SHIGGPRLER RATTDPDQYS
LGSYSSMQDC RGIYAGCPTV LSSPSSEELT QDQGDRVSLD AADSGRGSWT SCSSGSHDNI
QTMQQGRSWE TLAFGGGGGG GGIGGLPPGG PEALLGGPAA LWAAQARGSW ASASSSSSSA
AYWGEDSEGD TGTIKRRGGK DVNADPETSS ITSTGSEEAK QLGRPSPSPI TAGGKGLISR
KESRYREPPP TPPGYTALTI SDLAEGQHPA PSVPTSTATH SGRRPPDYTT ALQRSRMVTQ
SPDSHQAHQG AKQRAGGLHR TRSPAEEQEP EEEEEEDEQV SAV
//
