ID A0A3B5AAP2_9TELE Unreviewed; 347 AA.
AC A0A3B5AAP2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Adenosine deaminase like {ECO:0000313|Ensembl:ENSSPAP00000018503.1};
DE SubName: Full=Adenosine deaminase-like protein {ECO:0000313|RefSeq:XP_008277138.1};
GN Name=adal {ECO:0000313|RefSeq:XP_008277138.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000018503.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000018503.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008277138.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine;
CC Xref=Rhea:RHEA:16001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:59338, ChEBI:CHEBI:144842;
CC Evidence={ECO:0000256|ARBA:ARBA00036622};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16002;
CC Evidence={ECO:0000256|ARBA:ARBA00036622};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
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DR RefSeq; XP_008277138.1; XM_008278916.1.
DR AlphaFoldDB; A0A3B5AAP2; -.
DR STRING; 144197.ENSSPAP00000018503; -.
DR Ensembl; ENSSPAT00000018782.1; ENSSPAP00000018503.1; ENSSPAG00000013957.1.
DR GeneID; 103355215; -.
DR CTD; 161823; -.
DR GeneTree; ENSGT00950000183113; -.
DR OrthoDB; 20281at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR CDD; cd00443; ADA_AMPD; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR11409:SF42; ADENOSINE DEAMINASE-LIKE PROTEIN; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000694891}.
FT DOMAIN 12..337
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 347 AA; 39113 MW; E1FCA3B75F1EFE52 CRC64;
MDNDADFYRE LPKVELHAHL NGSVSFQTIE KLIRRKPQLN IEHSMTAIGK GQQRTLEECF
EVFKVIHKLV DTEEDILMVA TDVIREFAAD GVKYLELRST PREKKDTGLT KRSYVETIIK
AIQQCKNEGV DIDVRFLVAV DRRNGAEVAM ETVKLAEEFM LSSDGLVLGL DLSGDPTVGH
GKYLLPALEK AKNSGLKLSL HLSEVPTQMD ESDLLLNLPP DRIGHGTFLH PEVGGSQSLV
DKVVNNNIPL ELCLTSNVKG QTVPCYSKHH FNYWYQLGHP SVICTDDKGV FCTDLSQEYQ
LAASTFGLNH EDVWKLSQQA IDCIFAPEDV KQQLKQKWKE LHPQVFK
//
