UniProt: A0A3B5ACU3

Database: UniProt
Entry: A0A3B5ACU3_9TELE

LinkDB:  A0A3B5ACU3_9TELE 
Original site:  A0A3B5ACU3_9TELE

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Ontology (4)   
   GO (4)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (12)   
   InterPro (7)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
All databases (21)   

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ID   A0A3B5ACU3_9TELE        Unreviewed;       408 AA.
AC   A0A3B5ACU3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Transforming growth factor beta {ECO:0000256|PIRNR:PIRNR001787};
GN   Name=TGFB3 {ECO:0000313|Ensembl:ENSSPAP00000019283.1};
GN   Synonyms=LOC103363570 {ECO:0000313|RefSeq:XP_008288617.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000019283.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000019283.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_008288617.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Transforming growth factor beta-3 proprotein: Precursor of
CC       the Latency-associated peptide (LAP) and Transforming growth factor
CC       beta-3 (TGF-beta-3) chains, which constitute the regulatory and active
CC       subunit of TGF-beta-3, respectively. {ECO:0000256|ARBA:ARBA00003972}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR001787}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR001787,
CC       ECO:0000256|RuleBase:RU000354}.
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DR   RefSeq; XP_008288617.1; XM_008290395.1.
DR   AlphaFoldDB; A0A3B5ACU3; -.
DR   STRING; 144197.ENSSPAP00000019283; -.
DR   Ensembl; ENSSPAT00000019575.1; ENSSPAP00000019283.1; ENSSPAG00000014554.1.
DR   GeneID; 103363570; -.
DR   GeneTree; ENSGT00940000155747; -.
DR   OrthoDB; 5390486at2759; -.
DR   Proteomes; UP000261400; Unplaced.
DR   Proteomes; UP000694891; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR016319; TGF-beta.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR015618; TGFB3.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   PANTHER; PTHR11848:SF34; TRANSFORMING GROWTH FACTOR BETA-3 PROPROTEIN; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   PIRSF; PIRSF001787; TGF-beta; 1.
DR   PRINTS; PR01423; TGFBETA.
DR   PRINTS; PR01426; TGFBETA3.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR001787-1};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|PIRNR:PIRNR001787};
KW   Mitogen {ECO:0000256|ARBA:ARBA00023246, ECO:0000256|PIRNR:PIRNR001787};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001787};
KW   Signal {ECO:0000256|PIRNR:PIRNR001787}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT   CHAIN           22..408
FT                   /note="Transforming growth factor beta"
FT                   /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT                   /id="PRO_5041500930"
FT   DOMAIN          293..408
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   DISULFID        303..312
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT   DISULFID        311..374
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT   DISULFID        340..405
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT   DISULFID        344..407
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT   DISULFID        373
FT                   /note="Interchain"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
SQ   SEQUENCE   408 AA;  46989 MW;  42696BFB532EDB4B CRC64;
     MHMGKVLLFV LLLNCATLSS SLSTCATVDI DHVKRKRVEA IRGQILSKLR LTSPPHSLGP
     NKIPYQIQAL YNSTKELLEE LGRDRQQSCG QDNTETEYYA KEIYKFNMVY GPSESNDLVY
     CPKGITSKVF RFNVSAMERN STNLFRAEFR ALRVPNSTAK RNEQRIELYQ IVRPNEHIRK
     QRYIGAKNVL TKGTPEWVSF DVTETVREWL MNRGSNLGLE ISVHCPCHTF NPNGDIIDNE
     NEVLEVKFRG VDGDDEHSRL DLDHLKKKKE QYLPHLILMM IPPHRLDTQS TRRRKRALDT
     NYCFSNTEES CCVRRLHIDF RRDLDWKWIH EPSGYDANYC SGPCPYLRSS DTTHSSLLSL
     YNTLNPEASA SPCCVPQDLE PLTILYYSGR TPKVEQLSNM IVKSCKCS
//

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