UniProt: A0A3B5AEL2

Database: UniProt
Entry: A0A3B5AEL2_9TELE

LinkDB:  A0A3B5AEL2_9TELE 
Original site:  A0A3B5AEL2_9TELE

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Ontology (3)   
   GO (3)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (7)   
   InterPro (5)   
   Pfam (1)   
   SMART (1)   
All databases (15)   

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ID   A0A3B5AEL2_9TELE        Unreviewed;       468 AA.
AC   A0A3B5AEL2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=GDNF family receptor alpha-1 {ECO:0000256|PIRNR:PIRNR038071};
DE            Short=GDNF receptor alpha-1 {ECO:0000256|PIRNR:PIRNR038071};
GN   Name=GFRA1 {ECO:0000313|Ensembl:ENSSPAP00000012007.1};
GN   Synonyms=LOC103356746 {ECO:0000313|RefSeq:XP_008279231.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000012007.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000012007.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_008279231.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for GDNF. Mediates the GDNF-induced
CC       autophosphorylation and activation of the RET receptor.
CC       {ECO:0000256|PIRNR:PIRNR038071}.
CC   -!- SUBUNIT: 2 molecules of GDNFR-alpha are thought to form a complex with
CC       the disulfide-linked GDNF dimer and with 2 molecules of RET.
CC       {ECO:0000256|PIRNR:PIRNR038071}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC       Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC       {ECO:0000256|ARBA:ARBA00004589}.
CC   -!- SIMILARITY: Belongs to the GDNFR family.
CC       {ECO:0000256|ARBA:ARBA00005961, ECO:0000256|PIRNR:PIRNR038071}.
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DR   RefSeq; XP_008279231.1; XM_008281009.1.
DR   AlphaFoldDB; A0A3B5AEL2; -.
DR   Ensembl; ENSSPAT00000012213.1; ENSSPAP00000012007.1; ENSSPAG00000009091.1.
DR   GeneID; 103356746; -.
DR   CTD; 79376; -.
DR   GeneTree; ENSGT00940000155560; -.
DR   OrthoDB; 3899332at2759; -.
DR   Proteomes; UP000261400; Unplaced.
DR   Proteomes; UP000694891; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   InterPro; IPR003503; GDNF_rcpt_A1.
DR   InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR   PANTHER; PTHR10269:SF3; GDNF FAMILY RECEPTOR ALPHA-1; 1.
DR   PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR   Pfam; PF02351; GDNF; 3.
DR   PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR   PRINTS; PR01317; GDNFRALPHA1.
DR   PRINTS; PR01316; GDNFRECEPTOR.
DR   SMART; SM00907; GDNF; 3.
DR   SUPFAM; SSF110035; GDNF receptor-like; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR038071};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038071};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR038071};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR038071}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|PIRNR:PIRNR038071"
FT   CHAIN           25..468
FT                   /note="GDNF family receptor alpha-1"
FT                   /evidence="ECO:0000256|PIRNR:PIRNR038071"
FT                   /id="PRO_5041500996"
FT   DOMAIN          37..120
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          158..241
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          251..345
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
SQ   SEQUENCE   468 AA;  52345 MW;  879BD56899917643 CRC64;
     MQRKTMILAV LYVLLPLFDV LCYAEENLRA GATRLDCVRA SEQCLKEQAC STKYRTMRQC
     VAGGKESNFS MVAGLEAKDE CRSAMDALKQ SPLYNCRCKR GMKKEKNCLR IYWGIYQTLQ
     GNDFLEDSPY EPVNSRLSDI FRLAPIIGEP AVARENNCLN AAKACNLNDT CKKYRSAYIS
     PCTSRVSTAE VCNKRKCHKA LRQFFDKVPP KHSYGMLFCS CPLSDQTACS ERRRQTIVPV
     CSYEEKQKPN CLELQASCKT NYICRSRLAD FFVNCQPEPR SLSGCLKENY ADCLLSYSGL
     IGTVMTPNYL RSPKISVSPY CDCSNSGNNK DECDKFTEFF TDNTCLRNAI QAFGNGTDVG
     VWQPMSPVQT TTSTTTPYQR NRERNPNTID NHINTDPGIY HFCGSLQAQK LKSNSSVDGV
     LCVDPQIDGP STSNAILRNG AASRRPAGLA SLLPPLLWLW YCSLPGDL
//

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