ID A0A3B5AF27_9TELE Unreviewed; 1295 AA.
AC A0A3B5AF27;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000016484.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000016484.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) +
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00034408};
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR STRING; 144197.ENSSPAP00000016484; -.
DR Ensembl; ENSSPAT00000016745.1; ENSSPAP00000016484.1; ENSSPAG00000012358.1.
DR GeneTree; ENSGT00940000158259; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR018241; Anion_exchange_CS.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF14; ANION EXCHANGE PROTEIN 2; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR PROSITE; PS00219; ANION_EXCHANGER_1; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 731..753
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 765..796
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 816..841
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 848..866
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 914..931
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 951..968
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1002..1023
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1044..1068
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1126..1146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1176..1194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1200..1217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 370..645
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 702..1182
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..138
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1295 AA; 145202 MW; 8A2AADCF002A4D3B CRC64;
MSNPSAPNQI TDAVASVIHG PEAPASSLHG TPRPEEEDDG DLNKALGVQR FQQILSPAAV
VPEEQHHTYH EEDIEYHRHS SHHIHRPLSK LPSEGRRKKS SKKRKKDKDH KSSHASSSGA
IEEGEDEEDE EEEGTEPSSA ASEPEKVKSD VEFFVSDEDH AAKRGKESPH SARELDIIPQ
SGVGTDTEDA SSTDKPETAS PTAQSAPPEH PPLARVSSAS RSYDLQERRR TGNMTGTEQA
KYQRIPTDES EAQTLASADL DGIKSHRFED VPGMRRHLVR KSTKGQVVHI GKDHKEPTTR
SRKQDRTPHE PLPVVLYRSA SRPEGFLLDM DSGQMAGYQK VFVELNELTM DKNQEMQWKE
TARWIKFEED VEEETDRWGK PHVASLSFRS LLELRKTISH GAVLLDLDQK TLPGIAHQVV
EQMIISDQIK AEDRANVLRA LLLKHSHPSD EKEHTSHFPR NISAASLGSL ISHHHNANHN
HQPEPSVTDP LMGAVHSMMD ADTRIDMEKN EVQQKEPSLG PGMHRSKSKH ELKLLEKIPE
NAEATVVLVG SVDFLEQPTM AFVRLQEAVE LESVLEVPVP VRFLFVLLGP PTTSMDYHQI
GRSISTLMSD KQFHEAAYLA DDRQDLLNAI NSFLDCSIVL PPSEMGDDEL LRSVARFQRE
MLRKREEQGV KLSAKEPKSF EEKEALLTPL KKSDDPLQRT GRPFGGLIRD VRRRYPKYLS
DFKDALNSQC MAAVIFIYFA ALSPAITFGG LLGEKTEGLI GVSELIVSTA VQGVVFCLLG
AQPLLVVGFS GPLLVFEEAF YSFCKSNDIE YLTGRVWIGF WLIIIVIVTV AFEGSFLVRF
VSRFTQEIFS FLISLIFICE TFFKLVKIFK DHPLQRCSLV NDTNDGAFTE NITVMLSNST
LPVTVKVQGE PNTALLSLVL MAGTFFIAFY LRKFKNSAFF PGRFRRVIGD FGVPIAILIM
VLVDYGIQDT FTQKLSVPSG FSVTTPQKRG WFISPLGTDK PFPIWMMFAC CLPALLVFIL
IFMETQITTL IVSKKERMLV KGSGFHLDLL LIVVLGGSSA LFGLPWMAAA TVRSVTHVNA
LTVMSKAVAP GDKPRIQEVK EQRVTGLLVA ILVGMSIVIG DLLRQIPLAV LFGIFLYMGV
MSLNGIQLTE RMMLLLMPPK YHPDHTYVRK VRTLRMHLFT CIQVVCLAVL WAVMSTQASL
AFPFVLILTV PVKMFVLRRI FSVREMACVS LTSGGRSRHS SLSKKRRVLM KEVFKFWCFV
ISRFTDYDNS ARKEKRHVHT CIKFNYICGF TLMLC
//
