ID   A0A3B5AKQ2_9TELE        Unreviewed;       995 AA.
AC   A0A3B5AKQ2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Retinal guanylyl cyclase 2-like {ECO:0000313|Ensembl:ENSSPAP00000014112.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000014112.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000014112.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   AlphaFoldDB; A0A3B5AKQ2; -.
DR   STRING; 144197.ENSSPAP00000014112; -.
DR   Ensembl; ENSSPAT00000014353.1; ENSSPAP00000014112.1; ENSSPAG00000010649.1.
DR   GeneTree; ENSGT00940000164853; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   PANTHER; PTHR11920:SF228; RETINAL GUANYLYL CYCLASE 1; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..995
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017262142"
FT   TRANSMEM        436..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          775..905
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   COILED          712..739
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   995 AA;  110393 MW;  327E39A20CD96DB7 CRC64;
     MQLPWLLRAC LWLLCITQVW AATFKLALIG PWSCDPMFSR AMPTAAANLA LSRLQSDSGL
     SKGFWYDVKL LEEDCSASKA LTELGEMEGY GHAYIGPFNP ALCHAASLLA EHWEAGLASP
     GCLDTDWPNL PPITPPSRVL FTVLRFFRWA HVAVISAPTD LWVSTGQEVA SALRAMGLPI
     GPVVTMETQD KGGAQDALNE IREADQVKVV IMCMSSVLIG GEDQKELLLA ALDMGMVSDG
     YVFVPYDALL YAMPYQDTVF HQLTNSTRLR HAYSAVLTVT MASDQSFYEA FRQAQMSREI
     RSAVSAKEVS PMFGTIFNMV YFVAKAVEER RQAGGGHWVT GNQLAQSDGG FDFQGFNQVL
     YGGKGGRGLQ SRYVVLGSDG DRFMPTHSLA PTHTDGMIGN LRPLSRSFIF PGGKPPPASF
     CWFDPEEACS GGVNTLMMAA AVLLLCALIG AFLYWIRKHK RTVNVTKLIL TLDDIVFIDT
     QVSRKKLNDE SIMRSLLEIK TPFRSIARSY ILTTPESSNI GILEVHLFPC SRLFPCPHLI
     PCSTLYPCSH LFPCPHLFPS GSCLDRTLWF CKSLCLLEHR VWVLLQHRRS VFSLSLKSTE
     EELLWTAPEL LRSPIRGGSF AGDVFSFSII IQEVISRTLP YAMMDMPAHE IVERLKQPPP
     LCRPIVSVDE APAECLALMN ECWNEDPIKR PSFDDVFKQF RGINRGKRAN IIDSMLRMLE
     QYSSNLEDLI RERTDELEVE RNKTEKLVGQ LLPKSVAQAL KKGKPVRPEH YSDCTLYFSD
     IVGFTTISAL SEPIEVVDLL NDLYTMFDAI IATHDVYKVE TIGDAYMVAS GVPNRNGHRH
     AAEVSNMSLD ILHSIGAFKI KHMPEIKVKI RIGLHSGPVV AGVVGLTMPR YCLFGDTVTT
     ASHMEASGLP YRIHISLSTV KVLTSLKLGY HIDTRKAQVR SPAHTCSDPR CTGSRLEYLV
     VPPGGANYGF IQYRPEEAPL FGSGPTDRPS VIYTP
//