ID A0A3B5AR35_9TELE Unreviewed; 1043 AA.
AC A0A3B5AR35;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=GEM interacting protein {ECO:0000313|Ensembl:ENSSPAP00000022906.1};
DE SubName: Full=GEM-interacting protein isoform X1 {ECO:0000313|RefSeq:XP_008289384.1};
GN Name=gmip {ECO:0000313|RefSeq:XP_008289384.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000022906.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000022906.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008289384.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008289384.1; XM_008291162.1.
DR AlphaFoldDB; A0A3B5AR35; -.
DR STRING; 144197.ENSSPAP00000022906; -.
DR Ensembl; ENSSPAT00000023271.1; ENSSPAP00000022906.1; ENSSPAG00000017308.1.
DR GeneID; 103364141; -.
DR CTD; 51291; -.
DR GeneTree; ENSGT00950000183110; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20816; C1_GMIP-like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF16; GEM-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 101..361
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 490..536
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 546..748
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..768
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 117264 MW; B69F10F6A55F98AB CRC64;
MEENLVSNKD SSQVTDVKKV HHKSETKRYS EIFREFDNLD LSLISSAGED LLADIDSQSI
SESISADSAE LTEQQDVSSE DAICPQIRAE GNEADGNQSA QEADLALCRC EDGVETALQY
AKMWCRYAKD LLAWMEKRIS LEQEFSKNII KTAEGAKANV AQQEMMPLQY IYTMALEQDI
KNSVTSRRTS ELLQNRCYQA LAAKKNEIDK WRREFKEQWA REQRRMNEAV TALKKARQQY
FQRCDELEKA KAVTAKAVED TAGMKTLDKR RKSKDEAQTK VSEAELLYKQ CVSDARLHQD
ELVKVKERII SHIRKLICQG DTVLKEATVN MFYYQRQQTE PVPLGYHNLE LTCRSLEPGE
PYLLYILSKR RPEQPLQVFN FQEYAPQGKG HKRKTSGALS TLQDSSLITD DVCYRRPGDG
RKTGHSDSES IGGSQESLSS PANNIWRSPK STSTVAVSSD DPDDRDVVSE SEYLDGQPVK
VRTFSRAALT HRLRKMKSKM VKCKQCDNYI VVSGVECEEC GLALHRKCME VCQLECEHRK
GTVFGVDLSL LQRDRPDEVP FVVLRCTSEI ESRALSIQGV YRVSGSKPRI LKLCQAFEMQ
KEQVDLSDPS PHDITSILKH FFKELPEPLL TFDLYNDFIA VGKTIQHLSE REAPPDTNEI
MDVIHKLQKL LQKLPTYCYS TLQHLMCHLQ KVSENFENKM SPSNLGIVFG PTLLRPLVST
DMPMIALLET SYQAVLVEFL IKHHDKVFGL QRPSTPPPPA PTAPLPDTPP RASCSVEGAV
YADLEHEASS RERPHSLESR TIKRDSSEGY ISDKSSSNEA VDQLSPEANE RAVLALRGTL
SDPHGGSVVE PTPDFGIQPQ HRFTRQPVKY YRHHNPGTRL SNPCRTARQP ASPAMGHPGS
ADSSRSSSPE PRMQRLSQNL DVHFENTCQL KEPIATETKM DAPLSPREVV QYMLGLDLAF
TSPVAAASSC TTQAPTQEAA ARCQTDQNIN LTSNRQNAGR SHALCQSPKT VPTEHHLTSP
AQKILSGLKL RRSHSGKDEQ LFV
//
