ID A0A3B5ATR0_9TELE Unreviewed; 466 AA.
AC A0A3B5ATR0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Aristaless related homeobox {ECO:0000313|Ensembl:ENSSPAP00000021194.1};
DE SubName: Full=Homeobox protein ARX {ECO:0000313|RefSeq:XP_008293752.1};
GN Name=arx {ECO:0000313|RefSeq:XP_008293752.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000021194.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000021194.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008293752.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_008293752.1; XM_008295530.1.
DR AlphaFoldDB; A0A3B5ATR0; -.
DR STRING; 144197.ENSSPAP00000021194; -.
DR Ensembl; ENSSPAT00000021517.1; ENSSPAP00000021194.1; ENSSPAG00000015984.1.
DR GeneID; 103367497; -.
DR CTD; 30657; -.
DR GeneTree; ENSGT00940000160633; -.
DR OrthoDB; 3151856at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR GO; GO:0003322; P:pancreatic A cell development; IEA:Ensembl.
DR GO; GO:0021539; P:subthalamus development; IEA:Ensembl.
DR GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR GO; GO:0021794; P:thalamus development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR PANTHER; PTHR24329:SF337; HOMEOBOX PROTEIN ARX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 220..280
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 434..447
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 222..281
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 49933 MW; A2DECE7B1139C12C CRC64;
MSGQFEEDIH DRGERKSSKS PTLLSSYCID SILGRRSPCK VRLIGTQSLT GLPGRGELDK
AADGPTKEPL SLSADMHLPP KLRRLYGPGG KYLHDHAEKL DRERLLLEQA SDCLKISQAP
QVSISRSKSY RENASLSRGE DDQSPGEASE DGSLGLVELG PLKFEEDAGK EEESCGDAAA
LSPKDEERES LNAGDGDVRD GEDSVCLSAG SDSEEGMLKR KQRRYRTTFT SYQLEELERA
FQKTHYPDVF TREELAMRLD LTEARVQVWF QNRRAKWRKR EKAGVQAHPS GLPFPGPLTA
GHPLSHYLEG GPFPPHPHPA LESAWTAAAA AAAAFPGLAP PPHNGSAPPL ATPLGLGTFL
GTAAMFRHPA FIGPTFGRLF SSMGPLTSAS TAAALLRQPA PPVENPSHAG PVLPDPSSSS
SSSSSSAAAD RRASSIAALR LKAKEHSAQL TQLNILPTGA AGKEVC
//
