ID A0A3B5AVZ6_9TELE Unreviewed; 452 AA.
AC A0A3B5AVZ6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Iroquois homeobox 5 {ECO:0000313|Ensembl:ENSSPAP00000017687.1};
DE SubName: Full=Iroquois-class homeodomain protein IRX-5 isoform X2 {ECO:0000313|RefSeq:XP_008280161.1};
GN Name=irx5 {ECO:0000313|RefSeq:XP_008280161.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000017687.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000017687.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008280161.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR RefSeq; XP_008280161.1; XM_008281939.1.
DR AlphaFoldDB; A0A3B5AVZ6; -.
DR STRING; 144197.ENSSPAP00000017687; -.
DR Ensembl; ENSSPAT00000017961.1; ENSSPAP00000017687.1; ENSSPAG00000013366.1.
DR GeneID; 103357389; -.
DR CTD; 573346; -.
DR GeneTree; ENSGT00940000159483; -.
DR OrthoDB; 2915644at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0072498; P:embryonic skeletal joint development; IEA:Ensembl.
DR GO; GO:0032330; P:regulation of chondrocyte differentiation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR PANTHER; PTHR11211:SF17; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-5; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 115..172
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 117..173
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 175..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 48810 MW; DE799F5633B53916 CRC64;
MAYPQGYLYQ PSASLALYSC PAYSTSVISG PRTEELGRSS SGSAFAPYAG STAFTSASPG
YNSHLPYSAD AAAAATFTSY VSSPYDHTTG MAGSIGYHPY AAPLGTYPYG DPAYRKNATR
DATATLKAWL NEHRKNPYPT KGEKIMLAII TKMTLTQVST WFANARRRLK KENKMTWTPR
NRSEDEEEDE NIDLEKNDDD EPNKPTDKGD STDTEADHKL LNPGDIGCDR FKEENHGKDT
DPLLSDSELK DQEERTTELL PDSAKPTTSS PSAVPRGNQS VAQQDKPSDL SHAPGTVTSN
VTSVIHSPPS APKPKLWSLA EIATSSDRCK GSSDAPQACP GLGQSAVMGT NASPSRSSPQ
CPLPNSTVLS RPLYYTSPFY PGYTNYGGSF GHLHSNHGSV TTGSTAHFNG LNQTVLNRAE
ALVRESQKVR GQTQVDLCKD SPYELKKGMS NI
//
