ID A0A3B5AXZ9_9TELE Unreviewed; 1671 AA.
AC A0A3B5AXZ9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000022679.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000022679.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR Ensembl; ENSSPAT00000023044.1; ENSSPAP00000022679.1; ENSSPAG00000016455.1.
DR GeneTree; ENSGT00940000158289; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005450; VDCC_L_a1ssu.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF9; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR PRINTS; PR01634; LVDCCALPHA1S.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180, ECO:0000256|PIRSR:PIRSR602077-
KW 3}; Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 72..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 933..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1054..1083
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1126..1147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1167..1187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1277..1297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1365..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1405..1440
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 747..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 631
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1029
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1671 AA; 190433 MW; 5B9C13CE9A932609 CRC64;
NEMGGLGHGG NPPLSSYIMD EETLKRKQKE KLKKLMATGG NPRPARSLLF LTLRNPFRKA
CISIVEWKPF EIIILLAIFA NCVALAVYLP MPEEDSNNTN SNLESLEYIF LIIFSIECFL
KIVAYGFLFH ADAYLRNCWN ILDFVCVSVG LFTVAVDAIN HISGVEAPVG EKGGGFDMKA
LRAFRVLRPL RLVSGVPSLQ VVMNSILKSM LPLFHITLLV FFMVTIYSIM ALELFKCKMH
KTCYYTGTNI IATVENEKPA PCAQAGNGRR CAINGTECRA GWPGPNHGIT HFDNLGFSML
TVYQCITTQG WTDVLYWVND AIGMEWPWIF FTSLILVGSF FVLNLVLGVL SGEFTKEREK
AKSRGEFQKL RETQQLDEDL KGYMEWITQA EVIDNDQERQ GLLPLENGGS ENGNPVKMDT
MQLIIYYYKL ARKWNRLLRR KCRVYVKSKL FYWWVIMLVF FNTLAIATEH HKQSQRLTNW
QDNANKLLLS MFALEMFMKM YALGIPSYFM SLFNRFDCFV VSTGIMELIL VHMGVMSVMG
ISVLRCIRLL RLLKVTRYWT SLSNLVASLL NSVRSIACLL LLLFLFIVIF SLLGMQVFGG
KFNFPNQPKP RSTFDSFPQA LITVFQILTG EDWNAVMYEG IMAHGGPSMP GILVSIYFII
LFVCGNFILL NVFLAIAVDN LAEAESLTLA QKEKAEEKQR KKALRQVFLK EEKTNLAKKL
AEQRAKGVEG IPTTAKLKID EFESNVNEIK DPFPPADFPG DDEEEDPEMP DSPRPRPMAD
LQLKEEAVPM PEASSFFIFG PQNKFRKLCH RIINATTFTN IILLFILLSS ISLAAEDPID
PMSFRNQVLA YADIVFTSVF TAEIVLKMTT YGAILHKGSF CRNSFNILDL LVVSVSLLSM
GMESSAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AVKTIGNIVL VTMLLDFMFA
CIGVQLFKFY ACTDPDKMTE EKCKGWYIKY QEGALHEMEV REREWTNSEL NFDNIFNGML
ALFTISTFEG WPKVLYKAID SNLEDTGPVY DNRVAISIFF IIYLILIAFF MMNIFVGFVI
VTFQEQGEQE YKNCELDKNQ RQCVQYALKA RPLRCYIPKN PYQYQVWYIV TSCYFEYLMF
LLIMLNTMCL GMQHCNQSAH VTHLSDMLNV IFTVLFTVEM ILKLMAFKAK GYFGDPWNIF
DFVIVIGSVV DVILSEIDVS MSEVDPMQAI ASSENMSVSI TFFRLFRVMR LVKLLNRSEG
IRNLLWTFIK SLQALPYVAL LILMLFFIYA VVGMQIFGKI ALVDGTYINR NNNFQTFPQA
VLLLFRCATG EAWHEVMLAS MYGKKCDPKS DYLPGEEYTC GSNFAIIYFM SFYMLCAFLI
INLFVAVIMD NFDYLTRDWS ILGPQHLDEF KKIWAEYDPE ATGRIKHLDV VTLLRRIPPP
LGFGKFCPHR IACKRLVSMN MPLNSDGTVT FNATLFALVR TALKIKTEGN FEQANEDLRA
IIKKIWKRTS MKLLDQVIPP IGDDEVTVGK FYATFLIQDY FRKLKKRQEE YYGYGPTKKS
ASHEIQAGLR NIEEEAAPEL HRTISGDLIT EEEMDRGVEG ILRRQGSLFG NHSDPFAEGS
DLASASQATS QRPLQMAEGA ITNSNTSHRY VCSYYTNILP NLFRYFVSLG H
//
