ID A0A3B5AY06_9TELE Unreviewed; 1926 AA.
AC A0A3B5AY06;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=DENN domain containing 4C {ECO:0000313|Ensembl:ENSSPAP00000025336.1};
DE SubName: Full=DENN domain-containing protein 4C isoform X1 {ECO:0000313|RefSeq:XP_008294572.1};
GN Name=DENND4C {ECO:0000313|Ensembl:ENSSPAP00000025336.1};
GN Synonyms=dennd4c {ECO:0000313|RefSeq:XP_008294572.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000025336.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000025336.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008294572.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008294572.1; XM_008296350.1.
DR STRING; 144197.ENSSPAP00000025336; -.
DR Ensembl; ENSSPAT00000025753.1; ENSSPAP00000025336.1; ENSSPAG00000019065.1.
DR GeneID; 103368097; -.
DR CTD; 55667; -.
DR GeneTree; ENSGT00940000158215; -.
DR OrthoDB; 1079051at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0000813; C:ESCRT I complex; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR018798; MVB12A/B.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF17; DENN DOMAIN-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF10240; DUF2464; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891}.
FT DOMAIN 38..197
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 189..641
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 820..854
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 901..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1575..1609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1575..1595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1640..1655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1926 AA; 211789 MW; C55078721896FB74 CRC64;
MIEDKGHRVT DYFVVAGLTD KSTPLEQDLS ETKSSGPKAP ITDLAVINRS AGETVPEGFT
CIDSTYSGQP ANLNHGSLKS PELFLCYKRG RGKPPLIDIG VLYEGKERLI QGCEVIQATP
YGRCANVNNS SATSQRIFIT FRRAPPVQPQ NSLAVTDICV IVTSKGETPP HTFCKVDKNL
NCGMWGSSVF LCYKKSVSSA NSISYKAGLI FRYPEDDYES FPLSESVPLF CLPMGAKIEC
WAPNTRDPLP VFSTFVLTIS SGEKVYGSAI QFYEPYSVDL LSEKQKIQLG LLTTVEKKMI
PNRPVNTNKC ICLLSRWPFF ESFRKFLMFL YKLSVSGPHP LPIEKHISHF MHNVSFPSPQ
RPRILVQLSA HDTLILSQPV CTPLPLSGAD YGTLLMNLGS ENCATLLHFV LLESKILLHS
LRPAVLTGVA EAVVAMIFPL QWQCPYIPLC PLSLAGVLNA PLPFIVGVDS RYFDLYDPPP
DVVCVDLDTN TIYLSDEKRH SNWKNLPKKP CKSLINSLSN LHHQLATVSV RQTAQEGSAV
DMTPIEADFT WHKKKTALEM EIQEAFLRFM ASIIKGYRSY LKPITQAPSE KATAADSLYD
LQGFLKSRDR AHQKFYSQLT KTQIFIRFIE ECTFVSDKDT GLAFFDDCVE KLFPSDKITD
KGTKVEGESS EDTRLLELDE SQKSEHTVFV MPPEPPPNDG PEPAPRYTYK GFPRLQMSLF
DRPRVLRPAL NSRATWDSLS NSPALLAKRT KQEIKLAYKM AKRFYSNPPL WARCLFSHCY
SMWFICLPAA VRLAKSKSRA MQQAYNVLLK MRTTEVEVLD EVCYRVVMQL CGVWGLPVMA
VRVLVEMKKA GVHPNAITYG YYNKAVLESP WPSRNRSGLF MWTKLRNVLR GVTQFKQALN
RTSSKTGSTL TTTAASVGGS AVTDSDRLSH GSADSSSEVN GEENDVFAQS HDKGDAAGSH
CSTGRQSDQG YGSKDELHQE LAEASHTAVP SADERNNPKG QHNGGDIAGS VDSAVAVAEP
PSPVDVPSPV PSIVKLSTGS FDAGRETGTG KLFRRHSSKT DHVSPPDEDA SRQSEGVAKP
SQQQRQKSFS ERSCSFSAET RAGMRLERDV DHMASQMGAD ARILAAALSG GQSPPPNSVS
KALFKDLEEE PEDDQGLTLR TLEDSRGAPE ERKGDDKEVK GTEVDGENRQ RKLTETQDDE
SGARGATLER ADVEAGADPL SLLVSESEES ASVTSQELPR PVPAVVSRNL AEEIEMYMSL
RSPLGAKSSS MELQQSQGDS TDAPQPKQPI ERRSSLPVPP VKTPTGSPGD TPKRSPSTVT
RSKTFAAKTK TPGSAAASPG PRSASLTALV KSSQGGSLGS VINSISGIKM DTLLSGPKID
VLKSSMKQAA NVASKMWGAV ASAYNYSDDE DEQAQAGGGF PSHLDENMLS AHDLDESPER
RTIPGLVANG LNQSCTSLGS SSGSSDIGRG THQTHPTPGR AGRGPDSEQS SSHHASSSSI
YQNCALEVLM SSCSQCRSCE ALVYDEEIMA GWTADDSNLN TNCPFCRTAF LPLLHIEFHD
LRTMTGFFMN PSASGDSIHS TSTQPTASSS ADIKTPDLIS FPEEEPRETL DNRTATHKSL
IPEPVQSDPL GLLEHQAAGK QQRCSGTSLT RSNSVGGPLQ SLDYSQRPGH GVSTTSLPCS
LQEVSDGMGA KRPNPKPVSV PYLSPLVLRK ELETLLENEG DQVIYTHKFL SQHPIIFWNL
VWYFRRLDLP THLPGLILTS EHCNNGVQLP LTSLSQDSKQ VYVQLLWDNV NLHQEPGDPL
YQLWRTFMEK KGTLAPTDHQ EVRTLLNTIV RNIQTNDVYG PINLLIREIK RRPDGVKRQR
SIYREILFLS LVALGRENID VEAFDREYRL AYDELSAEQL KSLHRIDRPL SPSVQWCLKC
FGAPFI
//
