ID A0A3B5AZZ4_9TELE Unreviewed; 910 AA.
AC A0A3B5AZZ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Toll-like receptor 3 {ECO:0000313|Ensembl:ENSSPAP00000026500.1, ECO:0000313|RefSeq:XP_008280297.1};
GN Name=tlr3 {ECO:0000313|RefSeq:XP_008280297.1,
GN ECO:0000313|RefSeq:XP_008280298.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000026500.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000026500.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008280297.1, ECO:0000313|RefSeq:XP_008280298.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR RefSeq; XP_008280297.1; XM_008282075.1.
DR RefSeq; XP_008280298.1; XM_008282076.1.
DR AlphaFoldDB; A0A3B5AZZ4; -.
DR STRING; 144197.ENSSPAP00000026500; -.
DR Ensembl; ENSSPAT00000026933.1; ENSSPAP00000026500.1; ENSSPAG00000019984.1.
DR GeneID; 103357492; -.
DR CTD; 7098; -.
DR GeneTree; ENSGT00940000166529; -.
DR OrthoDB; 3428126at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_008280297.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..910
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041084122"
FT TRANSMEM 710..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 761..902
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 910 AA; 102484 MW; 9EF8BA9EF9B506CC CRC64;
MCSPRSCLLS WALIMCCLMM GPSYYVAAVK KNSCHVQDGR ADCSHLSLRE IPPDLPTNIF
SLDISHNRLV GLPPVSLKLY PGLVHLDASY NSISKLEEGL CQTLPLLQTL NLKHNQVHLL
KNEDLSHCTN LISLNMASNR LKLEGEPFSG LQSLKFLDVS INKLQSATLG SQPQLPRLVK
LNLAFNEFTA LKREDFSFLN QSSFLQLLNL SSVPLNTLET GCFKPISGLR TLILDGSKIG
TRVISKVCSA LSDTAIDALS LKKMNLITLT NTTFIGLNKT NVTFLDLSSN SMSKIEDGSF
QWLPKLQTLI MSDNNLKRLT NSSFMGLESL KKLQLTKALV KSSSSPIIND FSFQPLSSLE
SLILAGNKAL RITEHTFTGL TSLTELDLSG SSYTSLKYMT NRTLISLAGS PLTKLNLIGT
DINLINNGSF SFLRNLTILL LDYNFIRQSL TGGEFEGLDK VQEIHMSNNY QSVTLSSGSF
VGVPGLRVLT LGKSLRAEAL NQDPSPFRFL SNLTILDLSN NNIANIKESM LEGTVNLKVL
KLQHNNLARL WKSANLGGPV FFLKYTRNLI NLQLDYNGFD EIPVEALRGL TSLEELSLTN
NLLNSLKDSV FDDLTSLRVL RLQKNLITAV RPEVFKTPMS NLSLLVMEKN PFDCTCDSIL
WFTTWLNKTN MTSVPGLKDQ YKCNTPLTYF NRSIMDFDPL SCKDMTPFQA LYILSSTAVI
TLIVIALLVR FHGWRIQFYW NILINRTLGY SDAKLEEGRE FEYDAYVVYA DRDASWVERR
LVPLENEMCR FCLEDRDSVI GMPQLESIVD NMNKSRKILF VVTESLLKDP WCRRFKVYQA
LHQVIEASRD SVVLVFLQDV HDYKLSRSLF LRRGMLRSCC VLDWPVHKER VPAFHQKLLI
ALGMTNRLQD
//
