ID   A0A3B5B2B6_9TELE        Unreviewed;       499 AA.
AC   A0A3B5B2B6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=STEAP2 metalloreductase {ECO:0000313|Ensembl:ENSSPAP00000027738.1};
GN   Name=STEAP2 {ECO:0000313|Ensembl:ENSSPAP00000027738.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000027738.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000027738.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 Cu(+) + H(+) + NADP(+) = 2 Cu(2+) + NADPH;
CC         Xref=Rhea:RHEA:71771, ChEBI:CHEBI:15378, ChEBI:CHEBI:29036,
CC         ChEBI:CHEBI:49552, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         Evidence={ECO:0000256|ARBA:ARBA00036664};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71773;
CC         Evidence={ECO:0000256|ARBA:ARBA00036664};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 Fe(2+) + H(+) + NADP(+) = 2 Fe(3+) + NADPH;
CC         Xref=Rhea:RHEA:71767, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         Evidence={ECO:0000256|ARBA:ARBA00035766};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:71769;
CC         Evidence={ECO:0000256|ARBA:ARBA00035766};
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|ARBA:ARBA00001970};
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the STEAP family.
CC       {ECO:0000256|ARBA:ARBA00007729}.
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DR   AlphaFoldDB; A0A3B5B2B6; -.
DR   STRING; 144197.ENSSPAP00000027738; -.
DR   Ensembl; ENSSPAT00000028191.1; ENSSPAP00000027738.1; ENSSPAG00000020871.1.
DR   GeneTree; ENSGT00390000008042; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028939; P5C_Rdtase_cat_N.
DR   PANTHER; PTHR14239; DUDULIN-RELATED; 1.
DR   PANTHER; PTHR14239:SF6; METALLOREDUCTASE STEAP2; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   Pfam; PF01794; Ferric_reduct; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022496};
KW   Iron {ECO:0000256|ARBA:ARBA00022496};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022496}.
FT   DOMAIN          38..125
FT                   /note="Pyrroline-5-carboxylate reductase catalytic N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03807"
FT   DOMAIN          268..412
FT                   /note="Ferric oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01794"
SQ   SEQUENCE   499 AA;  56266 MW;  F8283EB381040F8B CRC64;
     MDSISMMCGS RSPACLLPSV IKNGVADVGN SRLPVQPTVA ILGSGDFSKC LTIRMLRCGF
     HVVVGSRHPK LAAHSFPHVV DVTHHEDAVG KANIVFLAIR REHYPILWDL KHLLEGKVLV
     DVSNNRRVNQ YPESNAEYLA SLLPGCVVVK GFNVISAWAM QQSCPKDAST QVFICSDSVE
     ARQQIMELCR QLNFQPVDMG PLSSSRDIEN MPIQLFPGWK GPVLAAVALA IFFFAYSFVR
     DIIHPYVKYK QSDFYKIPIE IVNRTLPTVA ITLLALVYLA GQLAAAHQLY YGTKYRHFPH
     WLEGWLQSRK QLGLLSFFLA AVHVLYSLCL PLRRSERYLL LNTAYQQVHV NVENAWNEEE
     VWRVEMYVSF GIMSLGLLSL LAITSIPSVH STLNWREFSF IQSTLGYIAL LIATFHGLLF
     GWKRAFEEEA YRFYLPPSFV VSLALPVCVI VGKVLMLLPC VAHKLHQIRR GLDNNQYRCQ
     RLEPVGSAAH ISPERVTIM
//