ID A0A3B5BAF8_9TELE Unreviewed; 475 AA.
AC A0A3B5BAF8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Serine protease HTRA1A-like {ECO:0000313|Ensembl:ENSSPAP00000022747.1, ECO:0000313|RefSeq:XP_008282802.1};
GN Name=LOC103359313 {ECO:0000313|RefSeq:XP_008282802.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000022747.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000022747.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008282802.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR RefSeq; XP_008282802.1; XM_008284580.1.
DR AlphaFoldDB; A0A3B5BAF8; -.
DR STRING; 144197.ENSSPAP00000022747; -.
DR Ensembl; ENSSPAT00000023112.1; ENSSPAP00000022747.1; ENSSPAG00000017165.1.
DR GeneID; 103359313; -.
DR GeneTree; ENSGT00940000156955; -.
DR OrthoDB; 2159919at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF128; SERINE PROTEASE HTRA1A; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00121; IB; 1.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670,
KW ECO:0000313|RefSeq:XP_008282802.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..475
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041074868"
FT DOMAIN 24..108
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 99..152
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 360..461
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 475 AA; 51077 MW; 2BB828A41B763902 CRC64;
MLWPLCVIVA FASWPADAQI SSRYAIGCPA RCDKSMCPRL PTDCQAGQTL DACHCCPVCA
SGEGEACGGS GKLGDPVCGE GLECSVSGGV AYTVTVRRRS KSGICVCKAT DPVCGSDGVS
YRNICELKRV SRRAQKLQQP PVLFIQRGAC GKAQDNPDSP RHKYNFIADV VERIAPSVVH
IELYRKMTYS KREVAVASGS GFVVSEDGQI VTNAHVVANK HRVKVELKSG ASYDAKIKDV
DEKSDIALIK IEAPTKLPVL LLGRSSDLRP GEFVVAIGSP FSLQNTVTTG IVSTTQRGGR
ELGLRNSDMD YIQTDAIINY GNSGGPLVNL DGEVIGINTL KVTAGISFAI PSDKIRQFLA
ESYDRQSRGR TDTKKKYIGV RMMTLTPALA KELKTRHRDF PDITSGAYVM EVIAKTPAAT
GGLKEHDVII SINGQRISTA TDVSAAIKKD STLRVVVRRG NEDAILTVVP MEIDP
//
