ID A0A3B5BBF4_9TELE Unreviewed; 1215 AA.
AC A0A3B5BBF4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Nidogen-1-like {ECO:0000313|Ensembl:ENSSPAP00000023092.1};
GN Name=NID1 {ECO:0000313|Ensembl:ENSSPAP00000023092.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000023092.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000023092.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B5BBF4; -.
DR STRING; 144197.ENSSPAP00000023092; -.
DR Ensembl; ENSSPAT00000023469.1; ENSSPAP00000023092.1; ENSSPAG00000017417.1.
DR GeneTree; ENSGT00940000156318; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00255; nidG2; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR46513:SF6; NIDOGEN-1; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF12947; EGF_3; 3.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 5.
DR SMART; SM00539; NIDO; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 11..175
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 361..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 405..638
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 637..678
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 679..721
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 726..769
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 770..806
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 811..888
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REPEAT 959..1001
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1002..1044
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1045..1089
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 189..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..339
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 858..865
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 1215 AA; 134805 MW; 2F4459EA68933F94 CRC64;
MMPSDFKMIA ALLGDLDNSD GQGKVYYRQD SSPDVLSQAA EHIRRAFPSD EGVEPTNTLI
VTWESMAARG TSGRGDGLDA KRNTFQLVLA SMESSSYAIL LYPRDGLQFL STSVEGESKL
LEAGFSEGTV SGWFWNTIQG TYFRTTTDDE TSIRDLTKKT NSARNGVWVY EIGATPIFIN
ITPGMATRSP EDNDATELPV TMSPRQPDET TTYETHMTRA TPSEYQPRYP EVENVTPGHI
KPSTAEPYQE YIESETVAPT STNTERVQPR YPDQLGPRYP DQTKTGYPVP ETLQPRYTIP
EPSEPRYSPV VPRYPNPDPV EPRYTNPEPV QPVPPHSRPQ HPQIVVVDEV EDLNVNVFAY
NLETCAHNRH KCSAFADCRD YSDGYCCHCR PGFYGNGRDC VAEGKPQRMN GKVNGRVFVG
SSPTPVELGN NDLHSYVVAN DGRAYVAISN INGTVGPSLQ PLSSLGGVIG WAFALEQPGY
QNGFSIVGGV FSRQAEVIFQ PGNERLSIKQ QFKGIDEHDH LVVSTTLEGR LPAIPQGYTV
QINPYKEIYQ YDRNLITSSS NRDYTVTSPD GDVQTRSYQW RQTITFQSCP HDESTRAALP
TQQLSVDQIF VMFDAGNNLI RYAMSNKIGS VHSGFPEQNP CFTGRHGCDI NAVCRPGEGL
QFSCECTTGF AGDGRYCQDI DECRDTPQVC GPNAVCSNQP GTFRCECSTG FVFASDGRTC
IEENRPVDHC QRGTHDCDVP ERALCRYTGG SAYVCSCLPG FTGDGRVCRD TDECQQDPCH
REASCSNTQG SYVCQCRPGF QGDGFQCSPS LSDCERHRET ARTGNSSGSG YFFFRPRPAV
RQYIPQCDER GAYWPTQCHD SIAQCWCVDA SGQEIPNTRT GPSSTPLCID QTVTPPPTGP
TPRPDVPPIA PGTHLLFAQS GKIEHVPLVG YSMKKEDAKP LLHIPDRVVI GVAYDCVEKM
VYWTDITGPA ISKAPLSGGD IIPVITTGLQ SPEGIAIDHV ARLLFWTDSM RDTVEVSKLD
GSQRRVLFDS DLVNPRPIVT NPAYGRLYWA DWDRDGPKIE MSNMDGTERT VLVKDDLGLP
NGLTFDPDNQ QLCWADAGTR KVECMDPHRR LRRSIVEGIQ YPFALVSFGR YLYYTDWRRE
AVVAVDRRLE REAEEFLPQK RSRVYGITTT PTKCPQAYNY CSNNAGCSHL CLPRLGGFTC
RCPDAAEGQC VERNQ
//
