ID   A0A3B5BCR5_9TELE        Unreviewed;       814 AA.
AC   A0A3B5BCR5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Axin-2-like {ECO:0000313|Ensembl:ENSSPAP00000023577.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000023577.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000023577.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; A0A3B5BCR5; -.
DR   Ensembl; ENSSPAT00000023956.1; ENSSPAP00000023577.1; ENSSPAG00000017754.1.
DR   GeneTree; ENSGT00940000157338; -.
DR   Proteomes; UP000261400; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd11582; Axin_TNKS_binding; 1.
DR   CDD; cd08707; RGS_Axin; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   Gene3D; 2.40.240.130; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR043581; Axin-like.
DR   InterPro; IPR014936; Axin_b-cat-bd.
DR   InterPro; IPR032101; Axin_TNKS-bd.
DR   InterPro; IPR001158; DIX.
DR   InterPro; IPR038207; DIX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46102; AXIN; 1.
DR   PANTHER; PTHR46102:SF1; AXIN-2; 1.
DR   Pfam; PF16646; AXIN1_TNKS_BD; 1.
DR   Pfam; PF08833; Axin_b-cat_bind; 1.
DR   Pfam; PF00778; DIX; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00021; DAX; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50841; DIX; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW   ProRule:PRU00069}.
FT   DOMAIN          87..206
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          732..814
FT                   /note="DIX"
FT                   /evidence="ECO:0000259|PROSITE:PS50841"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          608..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          375..402
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        445..459
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..637
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  89897 MW;  B72731AD247B058E CRC64;
     NVSASLRPLM DHIASSFSED APRPPVPGEE GEAPCYPGKL AMMKPLEPPK SVLLGSPGSS
     ARRNEDGLGE PEGSASPDSP LSRWTKSLHS LLGDQDGALL FRTFLEREKC VDTLDFWFAC
     NGFRQMDLKD TKTQRVAKAI YKRYIENNSI VAKQLKPATK TFIRDNIKKQ HIDSAMFDQA
     QTEIQTNMEE NAYQMFLTSD IYLEYVRTGG ENPSHVNSNG LGDLKVVCGY LPTLNEEEEW
     SCDFKAKALV GLSAKAQRAP VSLMERAYRS YKRGDSLNPC HVGSFAPVSS TNDSEVSSDA
     LTDDAMSVTD SSVDGIPPYK LGSKKQLHRE MQRNMRMNSQ VSLPAFPRTR RPPKEMVPME
     PAEFAAQLIS RLESLKREQD TISSLEERLQ QIQEEEERED TEIMGSAPQL SPHPLTLLSG
     SSDEDPQAIL DEHLSRVLKT PGCQSPAVIQ HSPRSSSPEH RPLTRGGFGI KALVRTGPSS
     VSSPDQGAFN LALGPNRTLV SRQSTKHIHH HYIHHHASPK SKEQIEREAA LRVHGVCSGS
     GECPPCQPYQ RSRSLGRETC GSISTDMCRS GAEDGVADRC VEDCGPLQLP SDTTDPAQNV
     LQWILESKRQ GRHKSHSTQS TKKSFGGSST QTHTWGGGGS CGHLRSHQPA QPFIQDPAMP
     PLPPPNTLAQ LEEACRRLEE VSTKTVKQRH PTSSLQREKT HLVPVQGGGS VPLSLPSPSP
     VGLLVSSLQS EDGETVVTYF FCGEEIPYRR TMKSHSLTLG HFKEQLRKKG NYRYYFKKAS
     DEFECGAVFE EVSDDGSLLP TYEGKILGKV ERME
//