ID   A0A3B5BFE6_9TELE        Unreviewed;       463 AA.
AC   A0A3B5BFE6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=N-lysine methyltransferase SETD6 {ECO:0000256|ARBA:ARBA00016973, ECO:0000256|PIRNR:PIRNR011771};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR011771};
GN   Name=setd6 {ECO:0000313|RefSeq:XP_008298936.1};
OS   Stegastes partitus (bicolor damselfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Stegastes.
OX   NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000024837.1, ECO:0000313|Proteomes:UP000261400};
RN   [1] {ECO:0000313|Ensembl:ENSSPAP00000024837.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_008298936.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Protein-lysine N-methyltransferase.
CC       {ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC       {ECO:0000256|PIRNR:PIRNR011771}.
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DR   RefSeq; XP_008298936.1; XM_008300714.1.
DR   AlphaFoldDB; A0A3B5BFE6; -.
DR   STRING; 144197.ENSSPAP00000024837; -.
DR   Ensembl; ENSSPAT00000025246.1; ENSSPAP00000024837.1; ENSSPAG00000018766.1.
DR   GeneID; 103371402; -.
DR   CTD; 79918; -.
DR   GeneTree; ENSGT00940000153577; -.
DR   OrthoDB; 51002at2759; -.
DR   Proteomes; UP000261400; Unplaced.
DR   Proteomes; UP000694891; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd19178; SET_SETD6; 1.
DR   Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR   Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR044430; SETD6_SET.
DR   PANTHER; PTHR13271:SF34; N-LYSINE METHYLTRANSFERASE SETD6; 1.
DR   PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   SUPFAM; SSF81822; RuBisCo LSMT C-terminal, substrate-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|PIRNR:PIRNR011771};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR011771};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694891};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PIRNR:PIRNR011771};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR011771}.
FT   DOMAIN          35..265
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          200..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..216
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  53181 MW;  1467D28FD6B57056 CRC64;
     MATEAKRVKV DDGAELTPLQ SFLQWCDRVG LVLSSKVYVS KEGTAAEYGM LAKDNIEEGE
     VLFTIPRSAL LHQGTTKVSA LLEKEKSSLE SSSGWVPLLL SLLYEYTTSQ SHWKPYLSLW
     TNFKTLDHPM FWPKEERERL LRGTGVPEAV DTDLNNIQRE YTDVVLPFMI RHPDLWNPNT
     HTLELYTKLV AFVMAYSFQE PQEEEDDEED EEEEQAPNPP MMVPMADMLN HVSNHNANLE
     FTPDSLKMVC VRPVRKGDEV FNTYGQMANW QLLHMYGFTE PYPSNSNDTA DIPVTNLYEV
     VTQGIQSDLY RQLKEEQWET LCEMMQEKAA FIFGKQGCLT DTELHTALKV LCMSQEEFSD
     FKDNEGWEED DEDDEKISQA FSNEGLPELK APWKWLIHEA ARLTLRSYGD EEGKLEDNMV
     DGDRALMEDK AAAAGLSCRQ WRALQVRYGQ KSILHRLMEL TKS
//