ID A0A3B5BGB2_9TELE Unreviewed; 1786 AA.
AC A0A3B5BGB2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DENN domain containing 4C {ECO:0000313|Ensembl:ENSSPAP00000025422.1};
GN Name=DENND4C {ECO:0000313|Ensembl:ENSSPAP00000025422.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000025422.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000025422.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSSPAT00000025841.1; ENSSPAP00000025422.1; ENSSPAG00000019065.1.
DR GeneTree; ENSGT00940000158215; -.
DR Proteomes; UP000261400; Unplaced.
DR GO; GO:0000813; C:ESCRT I complex; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR018798; MVB12A/B.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF17; DENN DOMAIN-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF10240; DUF2464; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT DOMAIN 38..197
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 189..639
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 818..852
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 898..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1060..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1449..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1449..1469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1490..1518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1786 AA; 197994 MW; 6915FB72A5A0D4BD CRC64;
MIEDKGHRVT DYFVVAGLTD KSTPLEQDLS ETKSSGPKAP ITDLAVINRS AGETVPEGFT
CIDSTYSGQP ANLNHGSLKS PELFLCYKRG RGKPPLIDIG VLYEGKERLI QGCEVIQATP
YGRCANVNNS SATSQRIFIT FRRAPPVQPQ NSLAVTDICV IVTSKGETPP HTFCKVDKNL
NCGMWGSSVF LCYKKSVSSA NSISYKAGLI FRYPEDDYES FPLSESVPLF CLPMGAKIEC
WAPNTRDPLP VFSTFVLTIS SGEKVYGSAI QFYEPYSVDL LSEKQKIQLG LLTTVEKKMI
PNRPVNTNKC ICLLSRWPFF ESFRKFLMFL YKLSVSGPHP LPIEKHISHF MHNVSFPSPQ
RPRILVQLSA HDTLILSQPV CTPLPLSGAD YGTLLMNLGS ENCATLLHFV LLESKILLHS
LRPAVLTGVA EAVVAMIFPL QWQCPYIPLC PLSLAGVLNA PLPFIVGVDS RYFDLYDPPP
DVVCVDLDTN TIYLSDEKRH SNWKNLPKKP CKSLINSLSN LHHQLATVRQ TAQEGSAVDM
TPIEADFTWH KKKTALEMEI QEAFLRFMAS IIKGYRSYLK PITQAPSEKA TAADSLYDLQ
GFLKSRDRAH QKFYSQLTKT QIFIRFIEEC TFVSDKDTGL AFFDDCVEKL FPSDKITDKG
TKVEGESSED TRLLELDESQ KSEHTVFVMP PEPPPNDGPE PAPRYTYKGF PRLQMSLFDR
PRVLRPALNS RATWDSLSNS PALLAKRTKQ EIKLAYKMAK RFYSNPPLWA RCLFSHCYSM
WFICLPAAVR LAKSKSRAMQ QAYNVLLKMR TTEVEVLDEV CYRVVMQLCG VWGLPVMAVR
VLVEMKKAGV HPNAITYGYY NKAVLESPWP SRNRSGLFMW TKLRNVLRGV TQFKQALNRT
SSKTGSTLTT TGRQSDQGYG SKDELHQELA EASHTAVPSA DERNNPKGQH NDCICVSSAG
TGKLFRRHSS KTDHVSPPDE DASRQSEGVA KPSQQQRQKS FSERSCSFSA ETRAGMRLER
DVDHMASQMG ADARILAAAL SGGQSPPPNS VSKALFKDLE EEPEDDQGLT LRTLEDSRGA
PEERKGDDKE VKGTEVDGEN RQRKLTETQD DESGARGATL ERADVEAGAD PLSLLVSESE
ESASVTSQEL PRPVPAVVSR NLAEEIEMYM SLRSPLGAKS SSMELQQSQG DSTDAPQPKQ
PIERRSSLPV PPVKTPTGSP GDTPKRSPST VTRSKTFAAK TKTPGSAAAS PGPRSASLTA
LVKSSQGGSL GSVINSISGI KMDTLLSGPK IDVLKSSMKQ AANVASKMWG AVASAYNYSD
DEVTQAGGGF PSHLDENMLS AHDLDESPER RTIPGLVANG LNQSCTSLGS SSGSSDIGRG
THQTRNCSQC RSCEALVYDE EIMAGWTADD SNLNTNCPFC RTAFLPLLHI EFHDLRTMTG
FFMNPSASGD SIHSTSTQPT ASSSADIKTP DLISFPEEEP RETLDNRTAT HKRYSFTSGK
QQRCSGTSLT RSNSVGGPLQ SLDYSQRPGH GVSTTSLPCS LQEVSDGMGA KRPNPKPVSV
PYLSPLVLRK ELETLLENEG DQVIYTHKFL SQHPIIFWNL VWYFRRLDLP THLPGLILTS
EHCNNGVQLP LTSLSQDSKQ VYVQLLWDNV NLHQEPGDPL YQLWRTFMEK KGTLAPTDHQ
EVRTLLNTIV RNIQTNDVYG PINLLIREIK RRPDGVKRQR SIYREILFLS LVALGRENID
VEAFDREYRL AYDELSAEQL KSLHRIDRPL SPSVQWCLKC FGAPFI
//
