ID A0A3B5BGD8_9TELE Unreviewed; 760 AA.
AC A0A3B5BGD8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Rho GTPase-activating protein 22-like {ECO:0000313|Ensembl:ENSSPAP00000029764.1, ECO:0000313|RefSeq:XP_008289621.1};
GN Name=ARHGAP22 {ECO:0000313|Ensembl:ENSSPAP00000029764.1};
GN Synonyms=LOC103364327 {ECO:0000313|RefSeq:XP_008289621.1};
OS Stegastes partitus (bicolor damselfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Stegastes.
OX NCBI_TaxID=144197 {ECO:0000313|Ensembl:ENSSPAP00000029764.1, ECO:0000313|Proteomes:UP000261400};
RN [1] {ECO:0000313|Ensembl:ENSSPAP00000029764.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008289621.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008289621.1; XM_008291399.1.
DR AlphaFoldDB; A0A3B5BGD8; -.
DR STRING; 144197.ENSSPAP00000029764; -.
DR Ensembl; ENSSPAT00000030247.1; ENSSPAP00000029764.1; ENSSPAG00000022394.1.
DR GeneID; 103364327; -.
DR CTD; 58504; -.
DR GeneTree; ENSGT00950000183015; -.
DR OrthoDB; 48967at2759; -.
DR Proteomes; UP000261400; Unplaced.
DR Proteomes; UP000694891; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF22; RHO GTPASE-ACTIVATING PROTEIN 22; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000694891}.
FT DOMAIN 59..167
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 177..372
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 372..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 668..741
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 402..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 85135 MW; 5089D220D3628596 CRC64;
MKWPQWRRTH CTDEFSVMKP SRTLQISDKP KELAARSKSM VLGELSRVSR PCSPLDQEKA
LKAGWLKRQR SIMKNWQLRW FVLRTEALYF YKDQDESKAQ GCIPLQGSQV NEVPANQDEP
GRHLFEIVPG GTGEKDRTGI SHESFLLMAN SQSDMEEWVR AIRRAIWAPL GGGVFGQHLE
ETMLYEAQCG PQRLVPVLVE QCVGFIREHG LKEEGLFRAP GQTNHVRELQ DAFDRGEKPV
FDSSTDVHTV ASLLKLYIRE LPEPIIPFSK YTQFLSCAQL LTKDKEMGII ELGKQVKSLP
QVNYNILKYI CKFLDEVQSH SNENKMSVQN LATVFGPNIL RPRVEDPVTM MEGSSQVQHL
MTVLISEHSR LYQREEPKTE TKVPPQRQDI QRCKVEWVSQ DDTDHLPSSG TGSKTPTETP
QSSTPSTESK TAASSPVTSE KGEDVRSEGK SKSKTEEKAD GKADSKTEGK SGSEVAVSPS
KQSKALPSWR CSFKGTATSG GPRGKIGGSA GDVSAAGGSN WLMNGLSSLR AHRRTTSSGE
RLKDSTLSLK DSTLSLRETT LSLKDSQRDS DEDSSRTSLS HRVLQSHRLS AYDNVAPSSL
SLPADTSSIW TSFEISLSEP EGSDKAVKLE QGQERPTEVR DSTNTVDHSA SGNEEDLTGA
NEDFTGMLTE LKQELKKQRT SYETCIRKLE ESCSKYQSQV NRLEEELDQE KKKFHMLEIR
LRNSERAHQD AENRNILLQQ EMEEFFKTLG DLTTGATRTN
//
